Tryptophan 2-monooxygenase

tryptophan 2-monooxygenase
Identifiers
EC number	1.13.12.3
CAS number	37256-65-8
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a tryptophan 2-monooxygenase (EC 1.13.12.3) is an enzyme that catalyzes the chemical reaction

L-tryptophan + O₂ $\rightleftharpoons$ (indol-3-yl)acetamide + CO₂ + H₂O

Thus, the two substrates of this enzyme are L-tryptophan and O₂, and its 3 products are (indol-3-yl)acetamide, CO₂, and H₂O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O₂ as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O with incorporation of one atom of oxygen (internal monooxygenases o internal mixed-function oxidases). The systematic name of this enzyme class is L-tryptophan:oxygen 2-oxidoreductase (decarboxylating). This enzyme participates in tryptophan metabolism.

References

• Kosuge T, Heskett MG, Wilson EE (1966). "Microbial synthesis and degradation of indole-3-acetic acid. I. The conversion of L-tryptophan to indole-3-acetamide by an enzyme system from Pseudomonas savastanoi". J. Biol. Chem. 241 (16): 3738–44. PMID 5916389.
• Kuo, TT and Kosuge T (1969). "Factors influencing the production and further metabolism of indole-3-acetic acid by Pseudomonas savastanoi". J. Gen. Appl. Microbiol. 15: 51–63. doi:10.2323/jgam.15.51.