Tuftelin

Tuftelin 1
Identifiers
Symbol	TUFT1
External IDs	OMIM: 600087 MGI: 109572 HomoloGene: 7985 GeneCards: TUFT1 Gene
Gene ontology Molecular function • protein binding • structural constituent of tooth enamel Cellular component • extracellular region • cytoplasm Biological process • bone mineralization • odontogenesis Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7286	22156
Ensembl	ENSG00000143367	ENSMUSG00000005968
UniProt	Q9NNX1	O08970
RefSeq (mRNA)	NM_001126337	NM_001293728
RefSeq (protein)	NP_001119809	NP_001280657
Location (UCSC)	Chr 1: 151.54 – 151.58 Mb	Chr 3: 94.61 – 94.66 Mb
PubMed search

Tuftelin is an acidic phosphorylated glycoprotein found in tooth enamel. In humans, the Tuftelin protein is encoded by the TUFT1 gene.^[1][2]

Function

This protein is formed for a short time during amelogenesis. The function of tuftelins is under contention, but it is proposed that it acts to start the mineralization process of enamel during tooth development.^[3][4]

Other significant proteins in enamel are amelogenins, enamelins, and ameloblastins.

Research

The human encoding gene for tuftelin (TUFT1) was cloned by Profs. Dany Deutsch and Aharon Palmon from the Hebrew University-Hadassah School of Dental Medicine in Jerusalem.^[2]

Interactions

Tuftelin has been shown to interact with TFIP11.^[5]

References

1. "Entrez Gene: TUFT1 tuftelin 1".
2. Deutsch D, Palmon A, Young MF, Selig S, Kearns WG, Fisher LW (July 1994). "Mapping of the human tuftelin (TUFT1) gene to chromosome 1 by fluorescence in situ hybridization". Mamm. Genome 5 (7): 461–2. doi:10.1007/BF00357011. PMID 7919663.
3. Deutsch D (June 1989). "Structure and function of enamel gene products". Anat. Rec. 224 (2): 189–210. doi:10.1002/ar.1092240209. PMID 2672884.
4. Deutsch D, Palmon A, Fisher LW, Kolodny N, Termine JD, Young MF (August 1991). "Sequencing of bovine enamelin ("tuftelin") a novel acidic enamel protein". J. Biol. Chem. 266 (24): 16021–8. PMID 1874744.
5. Paine, C T; Paine M L; Luo W; Okamoto C T; Lyngstadaas S P; Snead M L (July 2000). "A tuftelin-interacting protein (TIP39) localizes to the apical secretory pole of mouse ameloblasts". J. Biol. Chem. (UNITED STATES) 275 (29): 22284–92. doi:10.1074/jbc.M000118200. ISSN 0021-9258. PMID 10806191.

Further reading

• Deutsch D, Leiser Y, Shay B, et al. (2003). "The human tuftelin gene and the expression of tuftelin in mineralizing and nonmineralizing tissues.". Connect. Tissue Res. 43 (2–3): 425–34. doi:10.1080/03008200290001186. PMID 12489194.
• Deutsch D, Palmon A, Young MF, et al. (1994). "Mapping of the human tuftelin (TUFT1) gene to chromosome 1 by fluorescence in situ hybridization". Mamm. Genome 5 (7): 461–2. doi:10.1007/BF00357011. PMID 7919663.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Paine CT, Paine ML, Luo W, et al. (2000). "A tuftelin-interacting protein (TIP39) localizes to the apical secretory pole of mouse ameloblasts". J. Biol. Chem. 275 (29): 22284–92. doi:10.1074/jbc.M000118200. PMID 10806191.
• Bashir MM, Abrams WR, Tucker T, et al. (2000). "Molecular cloning and characterization of the bovine and human tuftelin genes". Connect. Tissue Res. 39 (1–3): 13–24; discussion 63–7. doi:10.3109/03008209809023908. PMID 11062985.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Mao Z, Shay B, Hekmati M, et al. (2002). "The human tuftelin gene: cloning and characterization". Gene 279 (2): 181–96. doi:10.1016/S0378-1119(01)00749-1. PMID 11733143.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.