Tyrosine phenol-lyase

tyrosine phenol-lyase
Identifiers
EC number 4.1.99.2
CAS number 9059-31-8
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a tyrosine phenol-lyase (EC 4.1.99.2) is an enzyme that catalyzes the chemical reaction

L-tyrosine + H2O \rightleftharpoons phenol + pyruvate + NH3

Thus, the two substrates of this enzyme are L-tyrosine and H2O, whereas its 3 products are phenol, pyruvate, and NH3.

This enzyme belongs to the family of lyases, specifically in the "catch-all" class of carbon-carbon lyases. The systematic name of this enzyme class is L-tyrosine phenol-lyase (deaminating; pyruvate-forming). Other names in common use include beta-tyrosinase, and L-tyrosine phenol-lyase (deaminating). This enzyme participates in tyrosine metabolism and nitrogen metabolism. It employs one cofactor, pyridoxal phosphate.

Structural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 1C7G, 1TPL, 2EZ1, 2EZ2, and 2TPL.

References

    This article is issued from Wikipedia - version of the Thursday, March 31, 2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.