U.S. Route 48 (disambiguation)

U.S. Route 48 is part of the Appalachian Development Highway System.

U.S. Route 48 may also refer to:

U.S. Route 48 (1926), one of the original routes in the United States Numbered Highways system
U.S. Route 48 (1969-1989), a highway in West Virginia and Maryland now designated as Interstate 68

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