UBASH3A

Ubiquitin associated and SH3 domain containing A
PDB rendering based on 2crn.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2CRN​
Identifiers
Symbols	UBASH3A ; CLIP4; STS-2; TULA; TULA-1
External IDs	OMIM: 605736 MGI: 1926074 HomoloGene: 56833 GeneCards: UBASH3A Gene
Gene ontology Molecular function • protein binding Cellular component • nucleus • cytosol • extracellular exosome Biological process • regulation of cytokine production • negative regulation of T cell receptor signaling pathway Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	53347	328795
Ensembl	ENSG00000160185	ENSMUSG00000042345
UniProt	P57075	Q3V3E1
RefSeq (mRNA)	NM_001001895	NM_177823
RefSeq (protein)	NP_001001895	NP_808491
Location (UCSC)	Chr 21: 42.4 – 42.45 Mb	Chr 17: 31.21 – 31.24 Mb
PubMed search

Ubiquitin-associated and SH3 domain-containing protein A is a protein that in humans is encoded by the UBASH3A gene.^[1][2]

References

1. Wattenhofer M, Shibuya K, Kudoh J, Lyle R, Michaud J, Rossier C, Kawasaki K, Asakawa S, Minoshima S, Berry A, Bonne-Tamir B, Shimizu N, Antonarakis SE, Scott HS (Apr 2001). "Isolation and characterization of the UBASH3A gene on 21q22.3 encoding a potential nuclear protein with a novel combination of domains". Hum Genet 108 (2): 140–7. doi:10.1007/s004390000453. PMID 11281453.
2. "Entrez Gene: UBASH3A ubiquitin associated and SH3 domain containing, A".

Further reading

• Smirnova EV, Collingwood TS, Bisbal C, et al. (2008). "TULA proteins bind to ABCE-1, a host factor of HIV-1 assembly, and inhibit HIV-1 biogenesis in a UBA-dependent fashion.". Virology 372 (1): 10–23. doi:10.1016/j.virol.2007.10.012. PMID 18006034.
• Collingwood TS, Smirnova EV, Bogush M, et al. (2007). "T-cell ubiquitin ligand affects cell death through a functional interaction with apoptosis-inducing factor, a key factor of caspase-independent apoptosis.". J. Biol. Chem. 282 (42): 30920–8. doi:10.1074/jbc.M706870200. PMID 17709377.
• Bertelsen V, Breen K, Sandvig K, et al. (2007). "The Cbl-interacting protein TULA inhibits dynamin-dependent endocytosis.". Exp. Cell Res. 313 (8): 1696–709. doi:10.1016/j.yexcr.2007.02.017. PMID 17382318.
• Hu YH, Warnatz HJ, Vanhecke D, et al. (2006). "Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins.". BMC Genomics 7: 155. doi:10.1186/1471-2164-7-155. PMC 1526728. PMID 16780588.
• Hoeller D, Crosetto N, Blagoev B, et al. (2006). "Regulation of ubiquitin-binding proteins by monoubiquitination.". Nat. Cell Biol. 8 (2): 163–9. doi:10.1038/ncb1354. PMID 16429130.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kowanetz K, Crosetto N, Haglund K, et al. (2004). "Suppressors of T-cell receptor signaling Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases.". J. Biol. Chem. 279 (31): 32786–95. doi:10.1074/jbc.M403759200. PMID 15159412.
• Feshchenko EA, Smirnova EV, Swaminathan G, et al. (2004). "TULA: an SH3- and UBA-containing protein that binds to c-Cbl and ubiquitin.". Oncogene 23 (27): 4690–706. doi:10.1038/sj.onc.1207627. PMID 15107835.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.