UBE1L2

Ubiquitin-like modifier activating enzyme 6
Identifiers
Symbols	UBA6 ; E1-L2; MOP-4; UBE1L2
External IDs	OMIM: 611361 MGI: 1913894 HomoloGene: 10080 GeneCards: UBA6 Gene
Gene ontology Molecular function • ubiquitin activating enzyme activity • protein binding • ATP binding • FAT10 activating enzyme activity Cellular component • cytoplasm • cytosol Biological process • ubiquitin-dependent protein catabolic process • learning • locomotory behavior • protein ubiquitination • amygdala development • hippocampus development • protein ubiquitination involved in ubiquitin-dependent protein catabolic process • dendritic spine development Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	55236	231380
Ensembl	ENSG00000033178	ENSMUSG00000035898
UniProt	A0AVT1	Q8C7R4
RefSeq (mRNA)	NM_018227	NM_172712
RefSeq (protein)	NP_060697	NP_766300
Location (UCSC)	Chr 4: 67.61 – 67.7 Mb	Chr 5: 86.11 – 86.17 Mb
PubMed search

Ubiquitin-like modifier-activating enzyme 6 is a protein that in humans is encoded by the UBA6 gene.^[1][2]

References

1. Pelzer C, Kassner I, Matentzoglu K, Singh RK, Wollscheid HP, Scheffner M, Schmidtke G, Groettrup M (Aug 2007). "UBE1L2, a novel E1 enzyme specific for ubiquitin". J Biol Chem 282 (32): 23010–4. doi:10.1074/jbc.C700111200. PMID 17580310.
2. "Entrez Gene: UBE1L2 ubiquitin-activating enzyme E1-like 2".

Further reading

• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Zhu H, Zhou ZM, Huo R, et al. (2004). "Identification and characteristics of a novel E1 like gene nUBE1L in human testis". Acta Biochim. Biophys. Sin. (Shanghai) 36 (3): 227–34. doi:10.1093/abbs/36.3.227. PMID 15202508.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Jin J, Li X, Gygi SP, Harper JW (2007). "Dual E1 activation systems for ubiquitin differentially regulate E2 enzyme charging". Nature 447 (7148): 1135–8. doi:10.1038/nature05902. PMID 17597759.
• Chiu YH, Sun Q, Chen ZJ (2007). "E1-L2 activates both ubiquitin and FAT10". Mol. Cell 27 (6): 1014–23. doi:10.1016/j.molcel.2007.08.020. PMID 17889673.