UBE4A

Ubiquitination factor E4A
PDB rendering based on 1wgm.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1WGM​
Identifiers
Symbols	UBE4A ; E4; UBOX2; UFD2
External IDs	OMIM: 603753 MGI: 2154580 HomoloGene: 3517 GeneCards: UBE4A Gene
Gene ontology Molecular function • protein binding • ligase activity • ubiquitin-ubiquitin ligase activity Cellular component • ubiquitin ligase complex • cytoplasm Biological process • protein polyubiquitination • ubiquitin-dependent protein catabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9354	140630
Ensembl	ENSG00000110344	ENSMUSG00000059890
UniProt	Q14139	E9Q735
RefSeq (mRNA)	NM_001204077	NM_145400
RefSeq (protein)	NP_001191006	NP_663375
Location (UCSC)	Chr 11: 118.36 – 118.4 Mb	Chr 9: 44.92 – 44.97 Mb
PubMed search

Ubiquitin conjugation factor E4 A is a protein that in humans is encoded by the UBE4A gene.^[1][2]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly.^[2]

References

1. Koegl M, Hoppe T, Schlenker S, Ulrich HD, Mayer TU, Jentsch S (Apr 1999). "A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly". Cell 96 (5): 635–44. doi:10.1016/S0092-8674(00)80574-7. PMID 10089879.
2. "Entrez Gene: UBE4A ubiquitination factor E4A (UFD2 homolog, yeast)".

Further reading

• Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, et al. (1995). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening.". Genomics 23 (1): 42–50. doi:10.1006/geno.1994.1457. PMID 7829101.
• Nagase T, Seki N, Tanaka A, et al. (1996). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1.". DNA Res. 2 (4): 167–74, 199–210. doi:10.1093/dnares/2.4.167. PMID 8590280.
• Mahoney JA, Odin JA, White SM, et al. (2002). "The human homologue of the yeast polyubiquitination factor Ufd2p is cleaved by caspase 6 and granzyme B during apoptosis.". Biochem. J. 361 (Pt 3): 587–95. doi:10.1042/0264-6021:3610587. PMC 1222341. PMID 11802788.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
• Contino G, Amati F, Pucci S, et al. (2004). "Expression analysis of the gene encoding for the U-box-type ubiquitin ligase UBE4A in human tissues.". Gene 328: 69–74. doi:10.1016/j.gene.2003.11.017. PMID 15019985.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Spinette S, Lengauer C, Mahoney JA, et al. (2006). "Ufd2, a novel autoantigen in scleroderma, regulates sister chromatid separation.". Cell Cycle 3 (12): 1638–44. doi:10.4161/cc.3.12.1345. PMID 15611659.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.