UBE4B

Ubiquitination factor E4B
Rendering based on PDB 2KRE​.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2KRE​, 3L1X​, 3L1Z​
Identifiers
Symbols	UBE4B ; E4; HDNB1; UBOX3; UFD2; UFD2A
External IDs	OMIM: 613565 MGI: 1927086 HomoloGene: 107623 GeneCards: UBE4B Gene
Gene ontology Molecular function • ligase activity • enzyme binding • ubiquitin-ubiquitin ligase activity Cellular component • ubiquitin ligase complex • nucleus • cytoplasm Biological process • granzyme-mediated apoptotic signaling pathway • response to UV • protein ubiquitination involved in ubiquitin-dependent protein catabolic process • proteasome-mediated ubiquitin-dependent protein catabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10277	63958
Ensembl	ENSG00000130939	ENSMUSG00000028960
UniProt	O95155	Q9ES00
RefSeq (mRNA)	NM_001105562	NM_022022
RefSeq (protein)	NP_001099032	NP_071305
Location (UCSC)	Chr 1: 10.03 – 10.18 Mb	Chr 4: 149.33 – 149.43 Mb
PubMed search

Ubiquitin conjugation factor E4 B is a protein that in humans is encoded by the UBE4B gene.^[1][2][3] The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly. This gene is also the strongest candidate in the neuroblastoma tumor suppressor genes.^[3]

References

1. Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
2. Koegl M, Hoppe T, Schlenker S, Ulrich HD, Mayer TU, Jentsch S (Apr 1999). "A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly". Cell 96 (5): 635–44. doi:10.1016/S0092-8674(00)80574-7. PMID 10089879.
3. "Entrez Gene: UBE4B ubiquitination factor E4B (UFD2 homolog, yeast)".

Further reading

• Onyango P, Lubyova B, Gardellin P, et al. (1998). "Molecular cloning and expression analysis of five novel genes in chromosome 1p36". Genomics 50 (2): 187–98. doi:10.1006/geno.1997.5186. PMID 9653645.
• Ohira M, Kageyama H, Mihara M, et al. (2000). "Identification and characterization of a 500-kb homozygously deleted region at 1p36.2-p36.3 in a neuroblastoma cell line". Oncogene 19 (37): 4302–7. doi:10.1038/sj.onc.1203786. PMID 10980605.
• Mahoney JA, Odin JA, White SM, et al. (2002). "The human homologue of the yeast polyubiquitination factor Ufd2p is cleaved by caspase 6 and granzyme B during apoptosis". Biochem. J. 361 (Pt 3): 587–95. doi:10.1042/0264-6021:3610587. PMC 1222341. PMID 11802788.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Kaneko C, Hatakeyama S, Matsumoto M, et al. (2003). "Characterization of the mouse gene for the U-box-type ubiquitin ligase UFD2a". Biochem. Biophys. Res. Commun. 300 (2): 297–304. doi:10.1016/S0006-291X(02)02834-6. PMID 12504083.
• Krona C, Ejeskär K, Abel F, et al. (2003). "Screening for gene mutations in a 500 kb neuroblastoma tumor suppressor candidate region in chromosome 1p; mutation and stage-specific expression in UBE4B/UFD2". Oncogene 22 (15): 2343–51. doi:10.1038/sj.onc.1206324. PMID 12700669.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Okumura F, Hatakeyama S, Matsumoto M, et al. (2005). "Functional regulation of FEZ1 by the U-box-type ubiquitin ligase E4B contributes to neuritogenesis". J. Biol. Chem. 279 (51): 53533–43. doi:10.1074/jbc.M402916200. PMID 15466860.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
• Spinette S, Mahoney JA, Rosen A (2006). "The MPAC domain is a novel mitotically regulated domain, removed by apoptotic protease cleavage during cell death". Biochem. Biophys. Res. Commun. 347 (4): 1103–12. doi:10.1016/j.bbrc.2006.06.194. PMID 16870146.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.

External links

• UBE4B human gene location in the UCSC Genome Browser.
• UBE4B human gene details in the UCSC Genome Browser.