UBL5

Ubiquitin-like 5
PDB rendering based on 1p0r.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1P0R​, 4PYU​
Identifiers
Symbols	UBL5 ; HUB1
External IDs	OMIM: 606849 MGI: 1913427 HomoloGene: 83305 GeneCards: UBL5 Gene
Gene ontology Molecular function • molecular_function • protein binding • protein tag Cellular component • nucleus • cytoplasm Biological process • mRNA splicing, via spliceosome • cellular protein modification process • biological_process • positive regulation of protein targeting to mitochondrion Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	59286	66177
Ensembl	ENSG00000198258	ENSMUSG00000084786
UniProt	Q9BZL1	Q9EPV8
RefSeq (mRNA)	NM_001048241	NM_025401
RefSeq (protein)	NP_001041706	NP_079677
Location (UCSC)	Chr 19: 9.83 – 9.83 Mb	Chr 9: 20.64 – 20.65 Mb
PubMed search

Ubiquitin-like protein 5 is a protein that in humans is encoded by the UBL5 gene.^[1]

It has been shown that in C. elegans mitochondria treated to lower expression of certain electron transport chain proteins during the L3/L4 stage, its expression levels is higher leading to increased lifespans. ^[2]

Ubiquitin-like proteins (UBLs) are thought to be reversible modulators of protein function rather than protein degraders like ubiquitin (MIM 191339).[supplied by OMIM]^[1]

References

1. "Entrez Gene: UBL5 ubiquitin-like 5".
2. Mitochondrial Stress Signals Revise an Old Aging Theory - DOI 10.1016/j.cell.2010.12.023

Further reading

• Friedman JS, Koop BF, Raymond V, Walter MA (2001). "Isolation of a ubiquitin-like (UBL5) gene from a screen identifying highly expressed and conserved iris genes". Genomics 71 (2): 252–5. doi:10.1006/geno.2000.6439. PMID 11161819.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Kantham L, Kerr-Bayles L, Godde N, et al. (2003). "Beacon interacts with cdc2/cdc28-like kinases". Biochem. Biophys. Res. Commun. 304 (1): 125–9. doi:10.1016/S0006-291X(03)00549-7. PMID 12705895.
• McNally T, Huang Q, Janis RS, et al. (2004). "Structural analysis of UBL5, a novel ubiquitin-like modifier". Protein Sci. 12 (7): 1562–6. doi:10.1110/ps.0382803. PMC 2323916. PMID 12824502.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wilkinson CR, Dittmar GA, Ohi MD, et al. (2005). "Ubiquitin-like protein Hub1 is required for pre-mRNA splicing and localization of an essential splicing factor in fission yeast". Curr. Biol. 14 (24): 2283–8. doi:10.1016/j.cub.2004.11.058. PMID 15620657.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.