Ubiquilin 4

Identifiers

UBQLN4 ; A1U; A1Up; C1orf6; CIP75; UBIN

External IDs

OMIM: 605440 HomoloGene: 41346 GeneCards: UBQLN4 Gene

Gene ontology
Molecular function	• protein binding • polyubiquitin binding • identical protein binding
Cellular component	• nucleus • cytoplasm • autophagosome • endoplasmic reticulum membrane • cytosol • cytoplasmic vesicle • nuclear proteasome complex • cytosolic proteasome complex • perinuclear region of cytoplasm
Biological process	• autophagy • regulation of proteasomal ubiquitin-dependent protein catabolic process • negative regulation of autophagosome maturation
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 1:
156.04 – 156.05 Mb

Chr 3:
88.55 – 88.57 Mb

PubMed search

Ubiquilin 4 is a protein in humans that is encoded by the UBQLN4 gene.^[1]^[2]^[3] Ubiquilin 4 regulates proteasomal protein degradation.^[4]

Similarity to Other Proteins

Human UBQLN4 shares a high degree of similarity with related ubiquilins including UBQLN1 and UBQLN2.^[5]

References

↑ "Entrez Gene: Ubiquilin 4". Retrieved 2013-06-27.
↑ Davidson JD, Riley B, Burright EN, Duvick LA, Zoghbi HY, Orr HT (September 2000). "Identification and characterization of an ataxin-1-interacting protein: A1Up, a ubiquitin-like nuclear protein". Hum. Mol. Genet. 9 (15): 2305–12. doi:10.1093/oxfordjournals.hmg.a018922. PMID 11001934.
↑ Matsuda M, Koide T, Yorihuzi T, Hosokawa N, Nagata K (January 2001). "Molecular cloning of a novel ubiquitin-like protein, UBIN, that binds to ER targeting signal sequences". Biochem. Biophys. Res. Commun. 280 (2): 535–40. doi:10.1006/bbrc.2000.4149. PMID 11162551.
↑ Riley BE, Xu Y, Zoghbi HY, Orr HT (October 2004). "The effects of the polyglutamine repeat protein ataxin-1 on the UbL-UBA protein A1Up". J. Biol. Chem. 279 (40): 42290–301. doi:10.1074/jbc.M406284200. PMID 15280365.
↑ Marín I (March 2014). "The ubiquilin gene family: evolutionary patterns and functional insights". BMC Evol Biol 14: 63. doi:10.1186/1471-2148-14-63. PMID 24674348.

External links

UBQLN4 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

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