UBTF

Upstream binding transcription factor, RNA polymerase I

PDB rendering based on 1k99.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols UBTF ; NOR-90; UBF; UBF-1; UBF1; UBF2
External IDs OMIM: 600673 MGI: 98512 HomoloGene: 7970 GeneCards: UBTF Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 7343 21429
Ensembl ENSG00000108312 ENSMUSG00000020923
UniProt P17480 A2AWT5
RefSeq (mRNA) NM_001076683 NM_001044383
RefSeq (protein) NP_001070151 NP_001037848
Location (UCSC) Chr 17:
44.21 – 44.22 Mb
Chr 11:
102.3 – 102.32 Mb
PubMed search

Nucleolar transcription factor 1 is a protein that in humans is encoded by the UBTF gene.[1][2]

Function

Upstream binding factor (UBF) is a transcription factor required for expression of the 18S, 5.8S, and 28S ribosomal RNAs, along with SL1 (a complex of TBP (MIM 600075) and three TBP-associated factors or 'TAFs'). Two UBF polypeptides, of 94 and 97 kD, exist in the human (Bell et al., 1988). UBF is a nucleolar phosphoprotein with both DNA binding and transactivation domains. Sequence-specific DNA binding to the core and upstream control elements of the human rRNA promoter is mediated through several HMG boxes (Jantzen et al., 1990).[supplied by OMIM][2]

Interactions

UBTF has been shown to interact with:

References

  1. Matera AG, Wu W, Imai H, O'Keefe CL, Chan EK (May 1997). "Molecular cloning of the RNA polymerase I transcription factor hUBF/NOR-90 (UBTF) gene and localization to 17q21.3 by fluorescence in situ hybridization and radiation hybrid mapping". Genomics 41 (1): 135–8. doi:10.1006/geno.1997.4647. PMID 9126496.
  2. 1 2 "Entrez Gene: UBTF upstream binding transcription factor, RNA polymerase I".
  3. Voit R, Kuhn A, Sander EE, Grummt I (July 1995). "Activation of mammalian ribosomal gene transcription requires phosphorylation of the nucleolar transcription factor UBF". Nucleic Acids Res. 23 (14): 2593–9. doi:10.1093/nar/23.14.2593. PMC 307079. PMID 7651819.
  4. Hannan KM, Hannan RD, Smith SD, Jefferson LS, Lun M, Rothblum LI (October 2000). "Rb and p130 regulate RNA polymerase I transcription: Rb disrupts the interaction between UBF and SL-1". Oncogene 19 (43): 4988–99. doi:10.1038/sj.onc.1203875. PMID 11042686.
  5. Voit R, Grummt I (November 2001). "Phosphorylation of UBF at serine 388 is required for interaction with RNA polymerase I and activation of rDNA transcription". Proc. Natl. Acad. Sci. U.S.A. 98 (24): 13631–6. doi:10.1073/pnas.231071698. PMC 61092. PMID 11698641.
  6. Zhai W, Comai L (August 2000). "Repression of RNA polymerase I transcription by the tumor suppressor p53". Mol. Cell. Biol. 20 (16): 5930–8. doi:10.1128/mcb.20.16.5930-5938.2000. PMC 86070. PMID 10913176.
  7. Lin CY, Tuan J, Scalia P, Bui T, Comai L (Dec 2002). "The cell cycle regulatory factor TAF1 stimulates ribosomal DNA transcription by binding to the activator UBF". Curr. Biol. 12 (24): 2142–6. doi:10.1016/s0960-9822(02)01389-1. PMID 12498690.

Further reading


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