UCK2
Uridine-cytidine kinase 2 is an enzyme that in humans is encoded by the UCK2 gene.[1]
The protein encoded by this gene catalyzes the phosphorylation of uridine and cytidine to uridine monophosphate (UMP) and cytidine monophosphate (CMP), respectively. This is the first step in the production of the pyrimidine nucleoside triphosphates required for RNA and DNA synthesis. In addition, an allele of this gene may play a role in mediating nonhumoral immunity to Hemophilus influenzae type B.[1]
Interactive pathway map
Click on genes, proteins and metabolites below to link to respective articles. [§ 1]
Fluorouracil (5-FU) Activity edit
- ↑ The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601".
References
Further reading
- Satlin A, Kucherlapati R, Ruddle FH (1976). "Assignment of the gene for human uridine monophosphate kinase to chromosome 1 using somatic cell hybrid clone panels". Cytogenet. Cell Genet. 15 (3): 146–52. doi:10.1159/000130513. PMID 172293.
- Jamil TP, Swallow DM, Povey S (1979). "A comparative study of the age-related patterns of decay of some nucleoside monophosphate kinases in human red cells". Biochem. Genet. 16 (11–12): 1219–32. doi:10.1007/BF00484542. PMID 220950.
- Ozaki K, Kuroki T, Hayashi S, Nakamura Y (1997). "Isolation of three testis-specific genes (TSA303, TSA806, TSA903) by a differential mRNA display method". Genomics 36 (2): 316–9. doi:10.1006/geno.1996.0467. PMID 8812458.
- Van Rompay AR, Johansson M, Karlsson A (1999). "Phosphorylation of deoxycytidine analog monophosphates by UMP-CMP kinase: molecular characterization of the human enzyme". Mol. Pharmacol. 56 (3): 562–9. PMID 10462544.
- Van Rompay AR, Norda A, Lindén K, et al. (2001). "Phosphorylation of uridine and cytidine nucleoside analogs by two human uridine-cytidine kinases". Mol. Pharmacol. 59 (5): 1181–6. PMID 11306702.
- Komatsu N, Kimura Y, Kido A, Oya M (2001). "Polymorphism of uridine monophosphate kinase: population study in Japanese and phenotyping in bloodstains". Int. J. Legal Med. 104 (1): 13–6. doi:10.1007/BF01816477. PMID 11453085.
- Koizumi K, Shimamoto Y, Azuma A, et al. (2001). "Cloning and expression of uridine/cytidine kinase cDNA from human fibrosarcoma cells". Int. J. Mol. Med. 8 (3): 273–8. doi:10.3892/ijmm.8.3.273. PMID 11494055.
- Pearman AT, Castro-Faria-Neto HC, McIntyre TM, et al. (2001). "Characterization of human UMP-CMP kinase enzymatic activity and 5' untranslated region". Life Sci. 69 (20): 2361–70. doi:10.1016/S0024-3205(01)01322-4. PMID 11681623.
- Liou JY, Dutschman GE, Lam W, et al. (2002). "Characterization of human UMP/CMP kinase and its phosphorylation of D- and L-form deoxycytidine analogue monophosphates". Cancer Res. 62 (6): 1624–31. PMID 11912132.
- Kashuba E, Kashuba V, Sandalova T, et al. (2002). "Epstein-Barr virus encoded nuclear protein EBNA-3 binds a novel human uridine kinase/uracil phosphoribosyltransferase". BMC Cell Biol. 3: 23. doi:10.1186/1471-2121-3-23. PMC 126255. PMID 12199906.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
- Pasti C, Gallois-Montbrun S, Munier-Lehmann H, et al. (2003). "Reaction of human UMP-CMP kinase with natural and analog substrates". Eur. J. Biochem. 270 (8): 1784–90. doi:10.1046/j.1432-1033.2003.03537.x. PMID 12694191.
- Suzuki NN, Koizumi K, Fukushima M, et al. (2004). "Crystallization and preliminary X-ray analysis of human uridine-cytidine kinase 2". Acta Crystallogr. D Biol. Crystallogr. 59 (Pt 8): 1477–8. doi:10.1107/S0907444903011533. PMID 12876357.
- Suzuki NN, Koizumi K, Fukushima M, et al. (2005). "Structural basis for the specificity, catalysis, and regulation of human uridine-cytidine kinase". Structure 12 (5): 751–64. doi:10.1016/j.str.2004.02.038. PMID 15130468.
- Murata D, Endo Y, Obata T, et al. (2005). "A crucial role of uridine/cytidine kinase 2 in antitumor activity of 3'-ethynyl nucleosides". Drug Metab. Dispos. 32 (10): 1178–82. doi:10.1124/dmd.104.000737. PMID 15280220.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Aldenhoven J, Chen Y, Moran C (2006). "Assignment of UCK2, ATF3 and RGS18 from human chromosome 1 to porcine chromosomes 4, 9 and 10 with somatic and radiation hybrid panels". Cytogenet. Genome Res. 112 (3–4): 341F. doi:10.1159/000089896. PMID 16484797.
- Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
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