UDP-2-acetamido-2-deoxy-ribo-hexuluronate aminotransferase

UDP-2-acetamido-2-deoxy-ribo-hexuluronate aminotransferase (EC 2.6.1.98, WbpE, WlbC) is an enzyme with systematic name UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate:2-oxoglutarate aminotransferase.^[1]^[2]^[3] This enzyme catalyses the following chemical reaction

UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate + 2-oxoglutarate

\rightleftharpoons

UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate + L-glutamate

This enzyme is a pyridoxal 5'-phosphate protein.

References

↑ Westman, E.L., McNally, D.J., Charchoglyan, A., Brewer, D., Field, R.A. and Lam, J.S. (2009). "Characterization of WbpB, WbpE, and WbpD and reconstitution of a pathway for the biosynthesis of UDP-2,3-diacetamido-2,3-dideoxy-D-mannuronic acid in Pseudomonas aeruginosa". J. Biol. Chem. 284 (18): 11854–11862. doi:10.1074/jbc.M808583200. PMC 2673254. PMID 19282284.
↑ Larkin, A. and Imperiali, B. (2009). "Biosynthesis of UDP-GlcNAc(3NAc)A by WbpB, WbpE, and WbpD: enzymes in the Wbp pathway responsible for O-antigen assembly in Pseudomonas aeruginosa PAO1". Biochemistry 48 (23): 5446–5455. doi:10.1021/bi900186u. PMC 2694220. PMID 19348502.
↑ Larkin, A., Olivier, N.B. and Imperiali, B. (2010). "Structural analysis of WbpE from Pseudomonas aeruginosa PAO1: a nucleotide sugar aminotransferase involved in O-antigen assembly". Biochemistry 49 (33): 7227–7237. doi:10.1021/bi100805b. PMID 20604544.

External links

UDP-2-acetamido-2-deoxy-ribo-hexuluronate aminotransferase at the US National Library of Medicine Medical Subject Headings (MeSH)

Transferase: nitrogenous groups (EC 2.6)

2.6.1: Transaminases	Aspartate transaminase GOT1 GOT2 Alanine transaminase GABA transaminase Tyrosine aminotransferase Ornithine aminotransferase Branched chain aminotransferase Alanine—glyoxylate transaminase AGXT

2.6.3: Oximinotransferases	Oximinotransferase

2.6.99: Other	Pyridoxine 5'-phosphate synthase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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