UHRF2

Ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase
PDB rendering based on 1wy8.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1WY8​, 1Z6U​, 2E6S​, 3OLN​, 4PW5​, 4PW6​, 4PW7​
Identifiers
Symbols	UHRF2 ; NIRF; RNF107; URF2
External IDs	OMIM: 615211 MGI: 1923718 HomoloGene: 17001 GeneCards: UHRF2 Gene
Gene ontology Molecular function • DNA binding • ubiquitin-protein transferase activity • protein binding • zinc ion binding • ligase activity • histone binding • ubiquitin protein ligase activity Cellular component • nucleus • nucleoplasm • nuclear heterochromatin Biological process • ubiquitin-dependent protein catabolic process • cell cycle • cell proliferation • maintenance of DNA methylation • protein ubiquitination • cell differentiation • regulation of cell cycle • protein autoubiquitination • positive regulation of cell cycle arrest • regulation of methylation-dependent chromatin silencing Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	115426	109113
Ensembl	ENSG00000147854	ENSMUSG00000024817
UniProt	Q96PU4	Q7TMI3
RefSeq (mRNA)	NM_152896	NM_144873
RefSeq (protein)	NP_690856	NP_659122
Location (UCSC)	Chr 9: 6.41 – 6.51 Mb	Chr 19: 30.03 – 30.09 Mb
PubMed search

E3 ubiquitin-protein ligase UHRF2 is an enzyme that in humans is encoded by the UHRF2 gene.^[1][2]

This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis.^[2]

References

1. Mori T, Li Y, Hata H, Ono K, Kochi H (Aug 2002). "NIRF, a novel RING finger protein, is involved in cell-cycle regulation". Biochem Biophys Res Commun 296 (3): 530–6. doi:10.1016/S0006-291X(02)00890-2. PMID 12176013.
2. "Entrez Gene: UHRF2 ubiquitin-like, containing PHD and RING finger domains, 2".

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Unoki M, Nishidate T, Nakamura Y (2004). "ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain.". Oncogene 23 (46): 7601–10. doi:10.1038/sj.onc.1208053. PMID 15361834.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Li Y, Mori T, Hata H, et al. (2004). "NIRF induces G1 arrest and associates with Cdk2.". Biochem. Biophys. Res. Commun. 319 (2): 464–8. doi:10.1016/j.bbrc.2004.04.190. PMID 15178429.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
• Mori T, Li Y, Hata H, Kochi H (2004). "NIRF is a ubiquitin ligase that is capable of ubiquitinating PCNP, a PEST-containing nuclear protein.". FEBS Lett. 557 (1–3): 209–14. doi:10.1016/S0014-5793(03)01495-9. PMID 14741369.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.