UNC5A

Unc-5 netrin receptor A
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4V2A​
Identifiers
Symbols	UNC5A ; UNC5H1
External IDs	OMIM: 607869 MGI: 894682 HomoloGene: 41474 GeneCards: UNC5A Gene
Gene ontology Molecular function • netrin receptor activity Cellular component • plasma membrane • integral component of membrane Biological process • apoptotic process • axon guidance • programmed cell death • anterior/posterior axon guidance • extrinsic apoptotic signaling pathway • extrinsic apoptotic signaling pathway in absence of ligand Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	90249	107448
Ensembl	ENSG00000113763	ENSMUSG00000025876
UniProt	Q6ZN44	Q8K1S4
RefSeq (mRNA)	NM_133369	NM_153131
RefSeq (protein)	NP_588610	NP_694771
Location (UCSC)	Chr 5: 176.81 – 176.88 Mb	Chr 13: 54.95 – 55.01 Mb
PubMed search

Netrin receptor UNC5A is a protein that in humans is encoded by the UNC5A gene.^[1]

UNC5A belongs to a family of netrin-1 (MIM 601614) receptors thought to mediate the chemorepulsive effect of netrin-1 on specific axons. For more information on UNC5 proteins, see UNC5C (MIM 603610).[supplied by OMIM]^[1]

Interactions

UNC5A has been shown to interact with MAGED1.^[2]

References

1. "Entrez Gene: UNC5A unc-5 homolog A (C. elegans)".
2. Williams, Megan E; Strickland Phyllis; Watanabe Ken; Hinck Lindsay (May 2003). "UNC5H1 induces apoptosis via its juxtamembrane region through an interaction with NRAGE". J. Biol. Chem. (United States) 278 (19): 17483–90. doi:10.1074/jbc.M300415200. ISSN 0021-9258. PMID 12598531.

Further reading

• Arakawa H (2005). "Netrin-1 and its receptors in tumorigenesis". Nat. Rev. Cancer 4 (12): 978–87. doi:10.1038/nrc1504. PMID 15573119.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Nagase T, Kikuno R, Ohara O (2002). "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins". DNA Res. 8 (6): 319–27. doi:10.1093/dnares/8.6.319. PMID 11853319.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Williams ME, Strickland P, Watanabe K, Hinck L (2003). "UNC5H1 induces apoptosis via its juxtamembrane region through an interaction with NRAGE". J. Biol. Chem. 278 (19): 17483–90. doi:10.1074/jbc.M300415200. PMID 12598531.
• Tanikawa C, Matsuda K, Fukuda S, et al. (2003). "p53RDL1 regulates p53-dependent apoptosis". Nat. Cell Biol. 5 (3): 216–23. doi:10.1038/ncb943. PMID 12598906.
• Thiebault K, Mazelin L, Pays L, et al. (2003). "The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment". Proc. Natl. Acad. Sci. U.S.A. 100 (7): 4173–8. doi:10.1073/pnas.0738063100. PMC 153067. PMID 12655055.
• Geisbrecht BV, Dowd KA, Barfield RW, et al. (2003). "Netrin binds discrete subdomains of DCC and UNC5 and mediates interactions between DCC and heparin". J. Biol. Chem. 278 (35): 32561–8. doi:10.1074/jbc.M302943200. PMID 12810718.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Llambi F, Lourenço FC, Gozuacik D, et al. (2005). "The dependence receptor UNC5H2 mediates apoptosis through DAP-kinase". EMBO J. 24 (6): 1192–201. doi:10.1038/sj.emboj.7600584. PMC 556396. PMID 15729359.