UPP1

Uridine phosphorylase 1
Rendering based on PDB 3EUE​.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3EUE​, 3EUF​, 3NBQ​
Identifiers
Symbols	UPP1 ; UDRPASE; UP; UPASE; UPP
External IDs	OMIM: 191730 MGI: 1097668 HomoloGene: 2524 ChEMBL: 4811 GeneCards: UPP1 Gene
EC number	2.4.2.3
Gene ontology Molecular function • uridine phosphorylase activity Cellular component • cytosol Biological process • nucleobase-containing compound metabolic process • pyrimidine nucleobase metabolic process • uridine catabolic process • nucleotide catabolic process • cellular response to glucose starvation • pyrimidine nucleoside salvage • UMP salvage • small molecule metabolic process • pyrimidine nucleoside catabolic process • nucleobase-containing small molecule metabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7378	22271
Ensembl	ENSG00000183696	ENSMUSG00000020407
UniProt	Q16831	P52624
RefSeq (mRNA)	NM_001287426	NM_001159401
RefSeq (protein)	NP_001274355	NP_001152873
Location (UCSC)	Chr 7: 48.09 – 48.11 Mb	Chr 11: 9.12 – 9.14 Mb
PubMed search

Uridine phosphorylase 1 is an enzyme that in humans is encoded by the UPP1 gene.^[1][2][3]

Interactions

UPP1 has been shown to interact with Vimentin.^[4]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles. ^{[§ 1]}

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|{{{bSize}}}px|alt=Fluorouracil (5-FU) Activity edit]]

Fluorouracil (5-FU) Activity edit

1. The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601".

References

1. Denney RM, Nichols EA, Ruddle FH (September 1979). "Assignment of a gene for uridine phosphorylase to chromosome 7". Cytogenet Cell Genet 22 (1–6): 195–9. doi:10.1159/000130934. PMID 752472.
2. Kanzaki A, Takebayashi Y, Bando H, Eliason JF, Watanabe Si S, Miyashita H, Fukumoto M, Toi M, Uchida T (January 2002). "Expression of uridine and thymidine phosphorylase genes in human breast carcinoma". Int J Cancer 97 (5): 631–5. doi:10.1002/ijc.10105. PMID 11807789.
3. "Entrez Gene: UPP1 uridine phosphorylase 1".
4. Russell, R L; Cao D; Zhang D; Handschumacher R E; Pizzorno G (April 2001). "Uridine phosphorylase association with vimentin. Intracellular distribution and localization". J. Biol. Chem. (United States) 276 (16): 13302–7. doi:10.1074/jbc.M008512200. ISSN 0021-9258. PMID 11278417.

Further reading

• Pizzorno G, Cao D, Leffert JJ, et al. (2002). "Homeostatic control of uridine and the role of uridine phosphorylase: a biological and clinical update". Biochim. Biophys. Acta 1587 (2–3): 133–44. doi:10.1016/s0925-4439(02)00076-5. PMID 12084455.
• Watanabe S, Uchida T (1995). "Cloning and expression of human uridine phosphorylase". Biochem. Biophys. Res. Commun. 216 (1): 265–72. doi:10.1006/bbrc.1995.2619. PMID 7488099.
• Russell RL, Cao D, Zhang D, et al. (2001). "Uridine phosphorylase association with vimentin. Intracellular distribution and localization". J. Biol. Chem. 276 (16): 13302–7. doi:10.1074/jbc.M008512200. PMID 11278417.
• Miyashita H, Takebayashi Y, Eliason JF, et al. (2002). "Uridine phosphorylase is a potential prognostic factor in patients with oral squamous cell carcinoma". Cancer 94 (11): 2959–66. doi:10.1002/cncr.10568. PMID 12115385.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Temmink OH, de Bruin M, Laan AC, et al. (2006). "The role of thymidine phosphorylase and uridine phosphorylase in (fluoro)pyrimidine metabolism in peripheral blood mononuclear cells". Int. J. Biochem. Cell Biol. 38 (10): 1759–65. doi:10.1016/j.biocel.2006.04.007. PMID 16798057.