UQCRQ

ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa
Identifiers
Aliases	UQCRQ, MC3DN4, QCR8, QP-C, QPC, UQCR7
External IDs	MGI: 107807 HomoloGene: 40942 GeneCards: 27089
Gene ontology Molecular function • ubiquinol-cytochrome-c reductase activity Cellular component • mitochondrial inner membrane • respiratory chain • mitochondrion • membrane Biological process • pons development • hydrogen ion transmembrane transport • pyramidal neuron development • respiratory electron transport chain • cellular metabolic process • hippocampus development • oxidation-reduction process • cerebellar Purkinje cell layer development • small molecule metabolic process • midbrain development • thalamus development • hypothalamus development • subthalamus development Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	27089	22272
Ensembl	ENSG00000164405	ENSMUSG00000044894
UniProt	O14949	Q9CQ69
RefSeq (mRNA)	NM_014402	NM_025352 XM_006533163
RefSeq (protein)	NP_055217.2	NP_079628.1 XP_006533226.1
Location (UCSC)	Chr 5: 132.87 – 132.87 Mb	Chr 11: 53.43 – 53.43 Mb
PubMed search
Wikidata

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Ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa is a protein that in humans is encoded by the UQCRQ gene.^[1]

Function

This gene encodes a ubiquinone-binding protein of low molecular mass. This protein is a small core-associated protein and a subunit of ubiquinol-cytochrome c reductase complex III, which is part of the mitochondrial respiratory chain.

References

1. "Entrez Gene: Ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa".

Further reading

• Schägger H, Brandt U, Gencic S, von Jagow G (1995). "Ubiquinol-cytochrome-c reductase from human and bovine mitochondria". Methods in Enzymology 260: 82–96. doi:10.1016/0076-6879(95)60132-5. PMID 8592474.
• Barel O, Shorer Z, Flusser H, Ofir R, Narkis G, Finer G, Shalev H, Nasasra A, Saada A, Birk OS (May 2008). "Mitochondrial complex III deficiency associated with a homozygous mutation in UQCRQ". American Journal of Human Genetics 82 (5): 1211–6. doi:10.1016/j.ajhg.2008.03.020. PMC 2427202. PMID 18439546.
• Wen JJ, Garg N (Dec 2004). "Oxidative modification of mitochondrial respiratory complexes in response to the stress of Trypanosoma cruzi infection". Free Radical Biology & Medicine 37 (12): 2072–81. doi:10.1016/j.freeradbiomed.2004.09.011. PMID 15544925.
• Sifroni KG, Damiani CR, Stoffel C, Cardoso MR, Ferreira GK, Jeremias IC, Rezin GT, Scaini G, Schuck PF, Dal-Pizzol F, Streck EL (Sep 2010). "Mitochondrial respiratory chain in the colonic mucosal of patients with ulcerative colitis". Molecular and Cellular Biochemistry 342 (1-2): 111–5. doi:10.1007/s11010-010-0474-x. PMID 20440543.
• Usui S, Yu L, Yu CA (May 1990). "The small molecular mass ubiquinone-binding protein (QPc-9.5 kDa) in mitochondrial ubiquinol-cytochrome c reductase: isolation, ubiquinone-binding domain, and immunoinhibition". Biochemistry 29 (19): 4618–26. doi:10.1021/bi00471a017. PMID 2164842.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.