USP13

Ubiquitin specific peptidase 13 (isopeptidase T-3)
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2L80​, 2LBC​
Identifiers
Symbols	USP13 ; ISOT3; IsoT-3
External IDs	OMIM: 603591 MGI: 1919857 HomoloGene: 68372 GeneCards: USP13 Gene
EC number	3.4.19.12
Gene ontology Molecular function • cysteine-type endopeptidase activity • ubiquitin-specific protease activity • protein binding • omega peptidase activity • zinc ion binding • ubiquitin protein ligase binding • ubiquitin binding • ubiquitin-like protein ligase binding • chaperone binding • proteasome binding • BAT3 complex binding • ubiquitin-specific protease activity involved in positive regulation of ERAD pathway Cellular component • lysosome Biological process • regulation of transcription, DNA-templated • autophagy • cell proliferation • regulation of autophagy • melanocyte differentiation • proteasome-mediated ubiquitin-dependent protein catabolic process • protein stabilization • regulation of proteasomal protein catabolic process • protein K63-linked deubiquitination • positive regulation of ERAD pathway • maintenance of unfolded protein involved in ERAD pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8975	72607
Ensembl	ENSG00000058056	ENSMUSG00000056900
UniProt	Q92995	Q5BKP2
RefSeq (mRNA)	NM_003940	NM_001013024
RefSeq (protein)	NP_003931	NP_001013042
Location (UCSC)	Chr 3: 179.65 – 179.79 Mb	Chr 3: 32.82 – 32.94 Mb
PubMed search

Ubiquitin carboxyl-terminal hydrolase 13 is an enzyme that in humans is encoded by the USP13 gene.^[1][2]

References

1. Puente XS, Sanchez LM, Overall CM, Lopez-Otin C (Jul 2003). "Human and mouse proteases: a comparative genomic approach". Nat Rev Genet 4 (7): 544–58. doi:10.1038/nrg1111. PMID 12838346.
2. "Entrez Gene: USP13 ubiquitin specific peptidase 13 (isopeptidase T-3)".

Further reading

• D'Andrea A, Pellman D (1999). "Deubiquitinating enzymes: a new class of biological regulators.". Crit. Rev. Biochem. Mol. Biol. 33 (5): 337–52. doi:10.1080/10409239891204251. PMID 9827704.
• Timms KM, Ansari-Lari MA, Morris W, et al. (1998). "The genomic organization of Isopeptidase T-3 (ISOT-3), a new member of the ubiquitin specific protease family (UBP).". Gene 217 (1-2): 101–6. doi:10.1016/S0378-1119(98)00341-2. PMID 9841226.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• McElhinny AS, Kakinuma K, Sorimachi H, et al. (2002). "Muscle-specific RING finger-1 interacts with titin to regulate sarcomeric M-line and thick filament structure and may have nuclear functions via its interaction with glucocorticoid modulatory element binding protein-1.". J. Cell Biol. 157 (1): 125–36. doi:10.1083/jcb.200108089. PMC 2173255. PMID 11927605.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.