USP15

Ubiquitin specific peptidase 15
PDB rendering based on 1w6v.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1W6V​, 3LMN​, 3PPA​, 3PV1​, 3T9L​, 4A3O​, 4A3P​
Identifiers
Symbols	USP15 ; UNPH-2; UNPH4
External IDs	OMIM: 604731 MGI: 101857 HomoloGene: 101542 GeneCards: USP15 Gene
EC number	3.4.19.12
Gene ontology Molecular function • cysteine-type endopeptidase activity • ubiquitin-specific protease activity • transforming growth factor beta receptor binding • protein binding • identical protein binding • SMAD binding • ubiquitinated histone binding Cellular component • nucleus • cytoplasm Biological process • transforming growth factor beta receptor signaling pathway • protein deubiquitination • BMP signaling pathway • negative regulation of transforming growth factor beta receptor signaling pathway • monoubiquitinated protein deubiquitination • histone H2B conserved C-terminal lysine deubiquitination • proteasome-mediated ubiquitin-dependent protein catabolic process • pathway-restricted SMAD protein phosphorylation • regulation of proteasomal protein catabolic process Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9958	14479
Ensembl	ENSG00000135655	ENSMUSG00000020124
UniProt	Q9Y4E8	Q8R5H1
RefSeq (mRNA)	NM_001252078	NM_001301628
RefSeq (protein)	NP_001239007	NP_001288557
Location (UCSC)	Chr 12: 62.26 – 62.42 Mb	Chr 10: 123.11 – 123.2 Mb
PubMed search

Ubiquitin carboxyl-terminal hydrolase 15 is an enzyme that in humans is encoded by the USP15 gene.^[1][2]

Ubiquitin (MIM 191339), a highly conserved protein involved in the regulation of intracellular protein breakdown, cell cycle regulation, and stress response, is released from degraded proteins by disassembly of the polyubiquitin chains. The disassembly process is mediated by ubiquitin-specific proteases (USPs). Also see USP1 (MIM 603478).[supplied by OMIM]^[2]

References

1. Puente XS, Sanchez LM, Overall CM, Lopez-Otin C (Jul 2003). "Human and mouse proteases: a comparative genomic approach". Nat Rev Genet 4 (7): 544–58. doi:10.1038/nrg1111. PMID 12838346.
2. "Entrez Gene: USP15 ubiquitin specific peptidase 15".

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• D'Andrea A, Pellman D (1999). "Deubiquitinating enzymes: a new class of biological regulators". Crit. Rev. Biochem. Mol. Biol. 33 (5): 337–52. doi:10.1080/10409239891204251. PMID 9827704.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
• de Jong RN, Ab E, Diercks T, et al. (2006). "Solution structure of the human ubiquitin-specific protease 15 DUSP domain". J. Biol. Chem. 281 (8): 5026–31. doi:10.1074/jbc.M510993200. PMID 16298993.
• Hetfeld BK, Helfrich A, Kapelari B, et al. (2005). "The zinc finger of the CSN-associated deubiquitinating enzyme USP15 is essential to rescue the E3 ligase Rbx1". Curr. Biol. 15 (13): 1217–21. doi:10.1016/j.cub.2005.05.059. PMID 16005295.
• Soboleva TA, Jans DA, Johnson-Saliba M, Baker RT (2005). "Nuclear-cytoplasmic shuttling of the oncogenic mouse UNP/USP4 deubiquitylating enzyme". J. Biol. Chem. 280 (1): 745–52. doi:10.1074/jbc.M401394200. PMID 15494318.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Angelats C, Wang XW, Jermiin LS, et al. (2003). "Isolation and characterization of the mouse ubiquitin-specific protease Usp15". Mamm. Genome 14 (1): 31–46. doi:10.1007/s00335-002-3035-0. PMID 12532266.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Baker RT, Wang XW, Woollatt E, et al. (1999). "Identification, functional characterization, and chromosomal localization of USP15, a novel human ubiquitin-specific protease related to the UNP oncoprotein, and a systematic nomenclature for human ubiquitin-specific proteases". Genomics 59 (3): 264–74. doi:10.1006/geno.1999.5879. PMID 10444327.
• Nagase T, Ishikawa K, Miyajima N, et al. (1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.