USP18

Ubiquitin specific peptidase 18
Identifiers
Symbols	USP18 ; ISG43; UBP43
External IDs	OMIM: 607057 MGI: 1344364 HomoloGene: 8047 GeneCards: USP18 Gene
Gene ontology Molecular function • cysteine-type endopeptidase activity • ubiquitin-specific protease activity • protein binding • ISG15-specific protease activity Cellular component • nucleus • cytosol Biological process • protein deubiquitination • cytokine-mediated signaling pathway • proteasome-mediated ubiquitin-dependent protein catabolic process • type I interferon signaling pathway • regulation of type I interferon-mediated signaling pathway • regulation of proteasomal protein catabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	11274	24110
Ensembl	ENSG00000184979	ENSMUSG00000030107
UniProt	Q9UMW8	Q9WTV6
RefSeq (mRNA)	NM_017414	NM_011909
RefSeq (protein)	NP_059110	NP_036039
Location (UCSC)	Chr 22: 18.15 – 18.18 Mb	Chr 6: 121.25 – 121.27 Mb
PubMed search

Ubiquitin specific peptidase 18 (USP18), also known as UBP43, is an enzyme that in human is encoded by the USP18 gene.^[1] USP18 is a member of the deubiquitinating protease family of enzymes. It is thought to remove ISG15 adducts from a broad range of protein substrates, a process known as deISGylation.^[1]

References

1. "Entrez Gene: USP18 ubiquitin specific peptidase 18".

Further reading

• Li XL, Blackford JA, Judge CS, et al. (2000). "RNase-L-dependent destabilization of interferon-induced mRNAs. A role for the 2-5A system in attenuation of the interferon response.". J. Biol. Chem. 275 (12): 8880–8. doi:10.1074/jbc.275.12.8880. PMID 10722734.
• Schwer H, Liu LQ, Zhou L, et al. (2000). "Cloning and characterization of a novel human ubiquitin-specific protease, a homologue of murine UBP43 (Usp18).". Genomics 65 (1): 44–52. doi:10.1006/geno.2000.6148. PMID 10777664.
• Kang D, Jiang H, Wu Q, et al. (2001). "Cloning and characterization of human ubiquitin-processing protease-43 from terminally differentiated human melanoma cells using a rapid subtraction hybridization protocol RaSH.". Gene 267 (2): 233–42. doi:10.1016/S0378-1119(01)00384-5. PMID 11313150.
• Malakhov MP, Malakhova OA, Kim KI, et al. (2002). "UBP43 (USP18) specifically removes ISG15 from conjugated proteins.". J. Biol. Chem. 277 (12): 9976–81. doi:10.1074/jbc.M109078200. PMID 11788588.
• Tokarz S, Berset C, La Rue J, et al. (2004). "The ISG15 isopeptidase UBP43 is regulated by proteolysis via the SCFSkp2 ubiquitin ligase.". J. Biol. Chem. 279 (45): 46424–30. doi:10.1074/jbc.M403189200. PMID 15342634.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Yan M, Luo JK, Ritchie KJ, et al. (2007). "Ubp43 regulates BCR-ABL leukemogenesis via the type 1 interferon receptor signaling.". Blood 110 (1): 305–12. doi:10.1182/blood-2006-07-033209. PMC 1896118. PMID 17374743.