USP2

Ubiquitin specific peptidase 2
PDB rendering based on 2hd5.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2HD5​, 2IBI​, 3NHE​, 3V6C​, 3V6E​
Identifiers
Symbols	USP2 ; UBP41; USP9
External IDs	OMIM: 604725 MGI: 1858178 HomoloGene: 3098 ChEMBL: 1293227 GeneCards: USP2 Gene
EC number	3.4.19.12
Gene ontology Molecular function • cysteine-type endopeptidase activity • ubiquitin-specific protease activity • protein binding • cyclin binding • ubiquitin protein ligase binding • identical protein binding • metal ion binding Cellular component • nucleus • cytoplasm • centrosome • cell cortex • perinuclear region of cytoplasm Biological process • negative regulation of transcription from RNA polymerase II promoter • cell cycle • muscle organ development • protein deubiquitination • circadian regulation of gene expression • entrainment of circadian clock by photoperiod • proteasome-mediated ubiquitin-dependent protein catabolic process • locomotor rhythm • positive regulation of mitotic cell cycle • circadian behavior • negative regulation of skeletal muscle tissue development • positive regulation of skeletal muscle tissue development • protein stabilization • regulation of proteasomal protein catabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9099	53376
Ensembl	ENSG00000036672	ENSMUSG00000032010
UniProt	O75604	O88623
RefSeq (mRNA)	NM_001243759	NM_016808
RefSeq (protein)	NP_001230688	NP_058088
Location (UCSC)	Chr 11: 119.36 – 119.38 Mb	Chr 9: 44.07 – 44.1 Mb
PubMed search

Ubiquitin carboxyl-terminal hydrolase 2 is an enzyme that in humans is encoded by the USP2 gene.^[1][2]

Ubiquitin (MIM 191339), a highly conserved protein involved in the regulation of intracellular protein breakdown, cell cycle regulation, and stress response, is released from degraded proteins by disassembly of the polyubiquitin chains. The disassembly process is mediated by ubiquitin-specific proteases (USPs). Also see USP1 (MIM 603478).[supplied by OMIM]^[2]

References

1. Puente XS, Sanchez LM, Overall CM, Lopez-Otin C (Jul 2003). "Human and mouse proteases: a comparative genomic approach". Nat Rev Genet 4 (7): 544–58. doi:10.1038/nrg1111. PMID 12838346.
2. "Entrez Gene: USP2 ubiquitin specific peptidase 2".

Further reading

• D'Andrea A, Pellman D (1999). "Deubiquitinating enzymes: a new class of biological regulators". Crit. Rev. Biochem. Mol. Biol. 33 (5): 337–52. doi:10.1080/10409239891204251. PMID 9827704.
• Baek SH, Choi KS, Yoo YJ, et al. (1997). "Molecular cloning of a novel ubiquitin-specific protease, UBP41, with isopeptidase activity in chick skeletal muscle". J. Biol. Chem. 272 (41): 25560–5. doi:10.1074/jbc.272.41.25560. PMID 9325273.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gewies A, Grimm S (2003). "UBP41 is a proapoptotic ubiquitin-specific protease". Cancer Res. 63 (3): 682–8. PMID 12566314.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
• Graner E, Tang D, Rossi S, et al. (2004). "The isopeptidase USP2a regulates the stability of fatty acid synthase in prostate cancer". Cancer Cell 5 (3): 253–61. doi:10.1016/S1535-6108(04)00055-8. PMID 15050917.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Stevenson LF, Sparks A, Allende-Vega N, et al. (2007). "The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2". EMBO J. 26 (4): 976–86. doi:10.1038/sj.emboj.7601567. PMC 1852834. PMID 17290220.