USP22

Ubiquitin specific peptidase 22
Identifiers
Symbols	USP22 ; USP3L
External IDs	OMIM: 612116 HomoloGene: 52664 GeneCards: USP22 Gene
EC number	3.4.19.12
Gene ontology Molecular function • transcription coactivator activity • cysteine-type endopeptidase activity • ubiquitin-specific protease activity • protein binding • zinc ion binding • H4 histone acetyltransferase activity • enzyme binding • ligand-dependent nuclear receptor transcription coactivator activity Cellular component • SAGA complex • SAGA-type complex Biological process • chromatin organization • transcription, DNA-templated • cell cycle • embryo development • histone ubiquitination • histone deubiquitination • protein deubiquitination • proteasome-mediated ubiquitin-dependent protein catabolic process • histone H4 acetylation • positive regulation of transcription, DNA-templated • positive regulation of mitotic cell cycle • regulation of proteasomal protein catabolic process Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23326	216825
Ensembl	ENSG00000124422	ENSMUSG00000042506
UniProt	Q9UPT9	Q5DU02
RefSeq (mRNA)	NM_015276	NM_001004143
RefSeq (protein)	NP_056091	NP_001004143
Location (UCSC)	Chr 17: 21 – 21.04 Mb	Chr 11: 61.15 – 61.18 Mb
PubMed search

Ubiquitin specific peptidase 22 is a protein that in humans is encoded by the USP22 gene on chromosome 17. ^[1] USP22 is known to function as a histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA.^[2]

References

1. "Entrez Gene: Ubiquitin specific peptidase 22". Retrieved 2014-01-14.
2. http://www.uniprot.org/uniprot/Q9UPT9#section_comments

Further reading

• Lang, G.; Bonnet, J.; Umlauf, D.; Karmodiya, K.; Koffler, J.; Stierle, M.; Devys, D.; Tora, L. (2011). "The Tightly Controlled Deubiquitination Activity of the Human SAGA Complex Differentially Modifies Distinct Gene Regulatory Elements". Molecular and Cellular Biology 31 (18): 3734–3744. doi:10.1128/MCB.05231-11. PMC 3165722. PMID 21746879.
• Wang, Y. -L.; Faiola, F.; Xu, M.; Pan, S.; Martinez, E. (2008). "Human ATAC is a GCN5/PCAF-containing Acetylase Complex with a Novel NC2-like Histone Fold Module That Interacts with the TATA-binding Protein". Journal of Biological Chemistry 283 (49): 33808–33815. doi:10.1074/jbc.M806936200. PMC 2590711. PMID 18838386.
• Armour, S. M.; Bennett, E. J.; Braun, C. R.; Zhang, X. -Y.; McMahon, S. B.; Gygi, S. P.; Harper, J. W.; Sinclair, D. A. (2013). "A High-Confidence Interaction Map Identifies SIRT1 as a Mediator of Acetylation of USP22 and the SAGA Coactivator Complex". Molecular and Cellular Biology 33 (8): 1487–1502. doi:10.1128/MCB.00971-12. PMC 3624249. PMID 23382074.
• Zhang, Y.; Yao, L.; Zhang, X.; Ji, H.; Wang, L.; Sun, S.; Pang, D. (2011). "Elevated expression of USP22 in correlation with poor prognosis in patients with invasive breast cancer". Journal of Cancer Research and Clinical Oncology 137 (8): 1245–1253. doi:10.1007/s00432-011-0998-9. PMID 21691749.
• Ling, S. B.; Sun, D. G.; Tang, B.; Guo, C.; Zhang, Y.; Liang, R.; Wang, L. M. (2012). "Knock-down of USP22 by small interfering RNA interference inhibits HepG2 cell proliferation and induces cell cycle arrest". Cellular and molecular biology (Noisy-le-Grand, France). 58 Suppl: OL1803–OL1808. PMID 23217440.
• Xiong, J.; Che, X.; Li, X.; Yu, H.; Gong, Z.; Li, W. (2012). Semsey, Szabolcs, ed. "Cloning and Characterization of the Human USP22 Gene Promoter". PLoS ONE 7 (12): e52716. doi:10.1371/journal.pone.0052716. PMC 3530469. PMID 23300749.
• Glinsky, G. V.; Berezovska, O.; Glinskii, A. B. (2005). "Microarray analysis identifies a death-from-cancer signature predicting therapy failure in patients with multiple types of cancer". Journal of Clinical Investigation 115 (6): 1503–1521. doi:10.1172/JCI23412. PMC 1136989. PMID 15931389.
• Xu, H.; Liu, Y. L.; Yang, Y. M.; Dong, X. S. (2011). "Knock-down of ubiquitin-specific protease 22 by micro-RNA interference inhibits colorectal cancer growth". International Journal of Colorectal Disease 27 (1): 21–30. doi:10.1007/s00384-011-1275-8. PMID 21773699.
• Liu, Y. L.; Yang, Y. M.; Xu, H.; Dong, X. S. (2011). "Aberrant expression of USP22 is associated with liver metastasis and poor prognosis of colorectal cancer". Journal of Surgical Oncology 103 (3): 283–289. doi:10.1002/jso.21802. PMID 21337558.