USP33

Ubiquitin specific peptidase 33
PDB rendering based on 2uzg.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2UZG​
Identifiers
Symbols	USP33 ; VDU1
External IDs	OMIM: 615146 MGI: 2159711 HomoloGene: 8996 GeneCards: USP33 Gene
EC number	3.4.19.12
Gene ontology Molecular function • G-protein coupled receptor binding • cysteine-type endopeptidase activity • ubiquitin-specific protease activity • protein binding • zinc ion binding • Ral GTPase binding • ubiquitin binding Cellular component • cytoplasm • autophagosome • Golgi apparatus • centrosome • VCB complex • intermediate filament cytoskeleton • perinuclear region of cytoplasm Biological process • ubiquitin-dependent protein catabolic process • endocytosis • axon guidance • regulation of G-protein coupled receptor protein signaling pathway • cellular response to starvation • regulation of autophagy • cell migration • protein deubiquitination • negative regulation of protein binding • positive regulation of protein binding • proteasome-mediated ubiquitin-dependent protein catabolic process • protein stabilization • centrosome duplication • regulation of proteasomal protein catabolic process • protein K63-linked deubiquitination • protein K48-linked deubiquitination Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23032	170822
Ensembl	ENSG00000077254	ENSMUSG00000025437
UniProt	Q8TEY7	Q8R5K2
RefSeq (mRNA)	NM_015017	NM_001076676
RefSeq (protein)	NP_055832	NP_001070144
Location (UCSC)	Chr 1: 77.7 – 77.76 Mb	Chr 3: 152.35 – 152.39 Mb
PubMed search

Ubiquitin carboxyl-terminal hydrolase 33 is an enzyme that in humans is encoded by the USP33 gene.^[1][2]

Interactions

USP33 has been shown to interact with DIO2,^[3] SELENBP1^[4] and Von Hippel-Lindau tumor suppressor.^[5]

References

1. Puente XS, Sánchez LM, Overall CM, López-Otín C (Jul 2003). "Human and mouse proteases: a comparative genomic approach". Nat Rev Genet 4 (7): 544–558. doi:10.1038/nrg1111. PMID 12838346.
2. "Entrez Gene: USP33 ubiquitin specific peptidase 33".
3. Curcio-Morelli C, Zavacki AM, Christofollete M, Gereben B, de Freitas BC, Harney JW, Li Z, Wu G, Bianco AC (Jul 2003). "Deubiquitination of type 2 iodothyronine deiodinase by von Hippel-Lindau protein-interacting deubiquitinating enzymes regulates thyroid hormone activation". J. Clin. Invest. 112 (2): 189–196. doi:10.1172/JCI18348. PMC 164294. PMID 12865408.
4. Jeong JY, Wang Y, Sytkowski AJ (Feb 2009). "Human selenium binding protein-1 (hSP56) interacts with VDU1 in a selenium-dependent manner". Biochem. Biophys. Res. Commun. 379 (2): 583–588. doi:10.1016/j.bbrc.2008.12.110. PMID 19118533.
5. Li Z, Na X, Wang D, Schoen SR, Messing EM, Wu G (Feb 2002). "Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein". J. Biol. Chem. 277 (7): 4656–4662. doi:10.1074/jbc.M108269200. PMID 11739384.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Kikuno R, Nagase T, Ishikawa K, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID 10470851.
• Li Z, Na X, Wang D, Schoen SR, Messing EM, Wu G (2002). "Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein". J. Biol. Chem. 277 (7): 4656–4662. doi:10.1074/jbc.M108269200. PMID 11739384.
• Li Z, Wang D, Na X, Schoen SR, Messing EM, Wu G (2002). "Identification of a deubiquitinating enzyme subfamily as substrates of the von Hippel-Lindau tumor suppressor". Biochem. Biophys. Res. Commun. 294 (3): 700–709. doi:10.1016/S0006-291X(02)00534-X. PMID 12056827.
• Curcio-Morelli C, Zavacki AM, Christofollete M, Gereben B, de Freitas BC, Harney JW, Li Z, Wu G, Bianco AC (2003). "Deubiquitination of type 2 iodothyronine deiodinase by von Hippel-Lindau protein-interacting deubiquitinating enzymes regulates thyroid hormone activation". J. Clin. Invest. 112 (2): 189–196. doi:10.1172/JCI18348. PMC 164294. PMID 12865408.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–1178. doi:10.1038/nature04209. PMID 16189514.
• Allen MD, Bycroft M (2007). "The solution structure of the ZnF UBP domain of USP33/VDU1". Protein Sci. 16 (9): 2072–2075. doi:10.1110/ps.072967807. PMC 2206988. PMID 17766394.