USP8

Ubiquitin specific peptidase 8

PDB rendering based on 1whb.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols USP8 ; HumORF8; SPG59; UBPY
External IDs OMIM: 603158 MGI: 1934029 HomoloGene: 3782 GeneCards: USP8 Gene
EC number 3.4.19.12
Orthologs
Species Human Mouse
Entrez 9101 84092
Ensembl ENSG00000138592 ENSMUSG00000027363
UniProt P40818 Q80U87
RefSeq (mRNA) NM_001128610 NM_001252580
RefSeq (protein) NP_001122082 NP_001239509
Location (UCSC) Chr 15:
50.42 – 50.51 Mb
Chr 2:
126.71 – 126.76 Mb
PubMed search

Ubiquitin carboxyl-terminal hydrolase 8 is an enzyme that in humans is encoded by the USP8 gene.[1][2][3]

Interactions

USP8 has been shown to interact with RNF41[4] and STAM2.[5][6]

References

  1. Puente XS, Sanchez LM, Overall CM, Lopez-Otin C (July 2003). "Human and mouse proteases: a comparative genomic approach". Nat Rev Genet 4 (7): 544–58. doi:10.1038/nrg1111. PMID 12838346.
  2. Janssen JW, Schleithoff L, Bartram CR, Schulz AS (May 1998). "An oncogenic fusion product of the phosphatidylinositol 3-kinase p85beta subunit and HUMORF8, a putative deubiquitinating enzyme". Oncogene 16 (13): 1767–72. doi:10.1038/sj.onc.1201695. PMID 9582025.
  3. "Entrez Gene: USP8 ubiquitin specific peptidase 8".
  4. Wu, Xiuli; Yen Lily; Irwin Lisa; Sweeney Colleen; Carraway Kermit L (September 2004). "Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8". Mol. Cell. Biol. (United States) 24 (17): 7748–57. doi:10.1128/MCB.24.17.7748-7757.2004. ISSN 0270-7306. PMC 506982. PMID 15314180.
  5. Kaneko, Tomonori; Kumasaka Takashi; Ganbe Tadashi; Sato Takao; Miyazawa Keiji; Kitamura Naomi; Tanaka Nobuo (November 2003). "Structural insight into modest binding of a non-PXXP ligand to the signal transducing adaptor molecule-2 Src homology 3 domain". J. Biol. Chem. (United States) 278 (48): 48162–8. doi:10.1074/jbc.M306677200. ISSN 0021-9258. PMID 13129930.
  6. Kato, M; Miyazawa K; Kitamura N (December 2000). "A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP". J. Biol. Chem. (UNITED STATES) 275 (48): 37481–7. doi:10.1074/jbc.M007251200. ISSN 0021-9258. PMID 10982817.

Further reading


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