Ubiquinol oxidase (H+-transporting)

Ubiquinol oxidase (H^+-transporting)
Identifiers
EC number	1.10.3.10
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Ubiquinol oxidase (H⁺-transporting) (EC 1.10.3.10, cytochrome bb3 oxidase, cytochrome bo oxidase, cytochrome bd-I oxidase) is an enzyme with systematic name ubiquinol:O₂ oxidoreductase (H⁺-transporting).^[1][2][3][4] This enzyme catalyses the following chemical reaction

2 ubiquinol + O₂ + n H⁺in $\rightleftharpoons$ 2 ubiquinone + 2 H₂O + n H⁺out

Ubiquinol oxidase contains a dinuclear centre comprising two hemes, or heme and copper.

References

1. Abramson, J., Riistama, S., Larsson, G., Jasaitis, A., Svensson-Ek, M., Laakkonen, L., Puustinen, A., Iwata, S. and Wikstrom, M. (2000). "The structure of the ubiquinol oxidase from Escherichia coli and its ubiquinone binding site". Nat. Struct. Biol. 7: 910–917. doi:10.1038/82824. PMID 11017202.
2. Belevich, I., Borisov, V.B., Zhang, J., Yang, K., Konstantinov, A.A., Gennis, R.B. and Verkhovsky, M.I. (2005). "Time-resolved electrometric and optical studies on cytochrome bd suggest a mechanism of electron-proton coupling in the di-heme active site". Proc. Natl. Acad. Sci. USA 102 (10): 3657–3662. doi:10.1073/pnas.0405683102. PMC 553295. PMID 15728392.
3. Yap, L.L., Lin, M.T., Ouyang, H., Samoilova, R.I., Dikanov, S.A. and Gennis, R.B. (2010). "The quinone-binding sites of the cytochrome bo₃ ubiquinol oxidase from Escherichia coli". Biochim. Biophys. Acta 1797 (12): 1924–1932. doi:10.1016/j.bbabio.2010.04.011. PMC 2922442. PMID 20416270.
4. Shepherd, M., Sanguinetti, G., Cook, G.M. and Poole, R.K. (2010). "Compensations for diminished terminal oxidase activity in Escherichia coli: cytochrome bd-II-mediated respiration and glutamate metabolism". J. Biol. Chem. 285 (24): 18464–18472. doi:10.1074/jbc.M110.118448. PMC 2881772. PMID 20392690.

External links

• Ubiquinol oxidase (H -transporting) at the US National Library of Medicine Medical Subject Headings (MeSH)