VCX

Variable charge, X-linked
Identifiers
Symbols	VCX ; VCX-10r; VCX-B1; VCX1; VCX10R; VCXB1
External IDs	OMIM: 300229 HomoloGene: 88395 GeneCards: VCX Gene
Gene ontology Molecular function • chromatin binding Cellular component • nucleus • nucleolus Biological process • chromatin organization • spermatogenesis • ribosome assembly Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	26609	n/a
Ensembl	ENSG00000169059	n/a
UniProt	Q9H320	n/a
RefSeq (mRNA)	NM_013452	n/a
RefSeq (protein)	NP_038480	n/a
Location (UCSC)	Chr X: 6.53 – 6.54 Mb	n/a
PubMed search		n/a

Variable charge X-linked protein 1 is a protein that in humans is encoded by the VCX gene.^[1][2][3]

This gene belongs to the VCX/Y gene family, which has multiple members on both X and Y chromosomes, and all are expressed exclusively in male germ cells. The X-linked members are clustered on chromosome Xp22 and Y-linked members are two identical copies of the gene within a palindromic region on Yq11. The family members share a high degree of sequence identity, with the exception that a 30-bp unit is tandemly repeated in X-linked members but occurs only once in Y-linked members. The VCX gene cluster is polymorphic in terms of copy number; different individuals may have a different number of VCX genes. VCX/Y genes encode small and highly charged proteins of unknown function. The presence of a putative bipartite nuclear localization signal suggests that VCX/Y members are nuclear proteins. This gene contains 10 repeats of the 30-bp unit.^[3]

References

1. Lahn BT, Page DC (Feb 2000). "A human sex-chromosomal gene family expressed in male germ cells and encoding variably charged proteins". Hum Mol Genet 9 (2): 311–9. doi:10.1093/hmg/9.2.311. PMID 10607842.
2. Fukami M, Kirsch S, Schiller S, Richter A, Benes V, Franco B, Muroya K, Rao E, Merker S, Niesler B, Ballabio A, Ansorge W, Ogata T, Rappold GA (Sep 2000). "A Member of a Gene Family on Xp22.3, VCX-A, Is Deleted in Patients with X-Linked Nonspecific Mental Retardation". Am J Hum Genet 67 (3): 563–73. doi:10.1086/303047. PMC 1287516. PMID 10903929.
3. "Entrez Gene: VCX variable charge, X-linked".

Further reading

• Zou SW, Zhang JC, Zhang XD, et al. (2004). "Expression and localization of VCX/Y proteins and their possible involvement in regulation of ribosome assembly during spermatogenesis". Cell Res. 13 (3): 171–7. doi:10.1038/sj.cr.7290161. PMID 12862317.
• Sy SM, Wong N, Mok TS, et al. (2003). "Genetic alterations of lung adenocarcinoma in relation to smoking and ethnicity". Lung Cancer 41 (1): 91–9. doi:10.1016/S0169-5002(03)00138-7. PMID 12826317.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.