VPRBP

Vpr (HIV-1) binding protein
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3WA0​, 4CC9​, 4P7I​, 4PXW​, 5AJA​
Identifiers
Symbols	VPRBP ; DCAF1
External IDs	MGI: 2445220 HomoloGene: 8805 GeneCards: VPRBP Gene
EC number	2.7.11.1
Gene ontology Molecular function • protein binding • ATP binding • histone kinase activity (H2A-T120 specific) Cellular component • nucleus • nucleolus • cytoplasm • COP9 signalosome Biological process • negative regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated • viral process • protein ubiquitination • B cell differentiation • V(D)J recombination • cell competition in a multicellular organism • histone H2A-T120 phosphorylation Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9730	321006
Ensembl	ENSG00000145041	ENSMUSG00000040325
UniProt	Q9Y4B6	Q80TR8
RefSeq (mRNA)	NM_001171904	NM_001015507
RefSeq (protein)	NP_001165375	NP_001015507
Location (UCSC)	Chr 3: 51.4 – 51.5 Mb	Chr 9: 106.82 – 106.88 Mb
PubMed search

Protein VPRBP is a protein that in humans is encoded by the VPRBP gene.^[1][2][3]

Interactions

VPRBP has been shown to interact with Merlin.^[4]

References

1. Zhao LJ, Mukherjee S, Narayan O (Jun 1994). "Biochemical mechanism of HIV-I Vpr function. Specific interaction with a cellular protein". J Biol Chem 269 (22): 15577–82. PMID 8195203.
2. Zhang S, Feng Y, Narayan O, Zhao LJ (Mar 2001). "Cytoplasmic retention of HIV-1 regulatory protein Vpr by protein-protein interaction with a novel human cytoplasmic protein VprBP". Gene 263 (1-2): 131–40. doi:10.1016/S0378-1119(00)00583-7. PMID 11223251.
3. "Entrez Gene: VPRBP Vpr (HIV-1) binding protein".
4. Huang, J; Chen J (Jul 2008). "VprBP targets Merlin to the Roc1-Cul4A-DDB1 E3 ligase complex for degradation". Oncogene (England) 27 (29): 4056–64. doi:10.1038/onc.2008.44. PMID 18332868.

Further reading

• Tan L, Ehrlich E, Yu XF (2007). "DDB1 and Cul4A are required for human immunodeficiency virus type 1 Vpr-induced G2 arrest.". J. Virol. 81 (19): 10822–30. doi:10.1128/JVI.01380-07. PMC 2045451. PMID 17626091.
• Wen X, Duus KM, Friedrich TD, de Noronha CM (2007). "The HIV1 protein Vpr acts to promote G2 cell cycle arrest by engaging a DDB1 and Cullin4A-containing ubiquitin ligase complex using VprBP/DCAF1 as an adaptor.". J. Biol. Chem. 282 (37): 27046–57. doi:10.1074/jbc.M703955200. PMID 17620334.
• Hrecka K, Gierszewska M, Srivastava S, et al. (2007). "Lentiviral Vpr usurps Cul4-DDB1[VprBP] E3 ubiquitin ligase to modulate cell cycle.". Proc. Natl. Acad. Sci. U.S.A. 104 (28): 11778–83. doi:10.1073/pnas.0702102104. PMC 1906728. PMID 17609381.
• Le Rouzic E, Belaïdouni N, Estrabaud E, et al. (2007). "HIV1 Vpr arrests the cell cycle by recruiting DCAF1/VprBP, a receptor of the Cul4-DDB1 ubiquitin ligase.". Cell Cycle 6 (2): 182–8. doi:10.4161/cc.6.2.3732. PMID 17314515.
• Borgne-Sanchez A, Dupont S, Langonné A, et al. (2007). "Targeted Vpr-derived peptides reach mitochondria to induce apoptosis of alphaVbeta3-expressing endothelial cells.". Cell Death Differ. 14 (3): 422–35. doi:10.1038/sj.cdd.4402018. PMID 16888644.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Zhao LJ, Zhang S, Chinnadurai G (2002). "Sox9 transactivation and testicular expression of a novel human gene, KIAA0800.". J. Cell. Biochem. 86 (2): 277–89. doi:10.1002/jcb.10214. PMID 12111997.
• Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.