VPREB3
| Pre-B lymphocyte 3 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbols | VPREB3 ; 8HS20; N27C7-2 | ||||||||||
| External IDs | OMIM: 605017 MGI: 98938 HomoloGene: 7598 GeneCards: VPREB3 Gene | ||||||||||
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| RNA expression pattern | |||||||||||
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| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | 29802 | 22364 | |||||||||
| Ensembl | ENSG00000128218 | ENSMUSG00000000903 | |||||||||
| UniProt | Q9UKI3 | n/a | |||||||||
| RefSeq (mRNA) | NM_013378 | NM_009514 | |||||||||
| RefSeq (protein) | NP_037510 | NP_033540 | |||||||||
| Location (UCSC) |
Chr 22: 23.75 – 23.75 Mb |
Chr 10: 75.94 – 75.95 Mb | |||||||||
| PubMed search | |||||||||||
Pre-B lymphocyte protein 3 is a protein that in humans is encoded by the VPREB3 gene.[1][2][3][4]
The VPREB3 gene product is the human homologue of the mouse VpreB3 (8HS20) protein, and is specifically expressed in cell lines representative of all stages of B-lymphocyte differentiation. It is also related to VPREB1 and other members of the immunoglobulin supergene family. The VPREB3 protein apparently associates with membrane mu heavy chains early in the course of pre-B cell receptor biosynthesis. The precise function of VPREB3 is not known, but it may contribute to mu chain transport in pre-B cells.[2][4] In humans, besides the bone marrow and secondary lymphoid tissues such as the tonsils, the VPREB3 protein is also present in Purkinje cells of the cerebellum and in the zona glomerulosa of the adrenal.[2]
References
- ↑ Rosnet O, Mattei MG, Delattre O, Schiff C (Apr 2000). "VPREB3: cDNA characterization and expression in human and chromosome mapping in human and mouse". Cytogenet Cell Genet 87 (3–4): 205–8. doi:10.1159/000015468. PMID 10702669.
- 1 2 3 Felizola SJ, Katsu K, Ise K, Nakamura Y, Arai Y, Satoh F, Sasano H. (2015). "Pre-B lymphocyte protein 3 (VPREB3) expression in the adrenal cortex: precedent for non-immunological roles in normal and neoplastic human tissues.". Endocrine Pathology. [in press].
- ↑ Rosnet O, Blanco-Betancourt C, Grivel K, Richter K, Schiff C (Mar 2004). "Binding of free immunoglobulin light chains to VpreB3 inhibits their maturation and secretion in chicken B cells". J Biol Chem 279 (11): 10228–36. doi:10.1074/jbc.M312169-A200. PMID 14670953.
- 1 2 "Entrez Gene: VPREB3 pre-B lymphocyte gene 3".
Further reading
- Melchers F, Karasuyama H, Haasner D, et al. (1993). "The surrogate light chain in B-cell development". Immunol. Today 14 (2): 60–8. doi:10.1016/0167-5699(93)90060-X. PMID 8166770.
- Ohnishi K, Takemori T (1994). "Molecular components and assembly of mu.surrogate light chain complexes in pre-B cell lines". J. Biol. Chem. 269 (45): 28347–53. PMID 7961773.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
- Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Rangel R, McKeller MR, Sims-Mourtada JC, et al. (2005). "Assembly of the kappa preB receptor requires a V kappa-like protein encoded by a germline transcript". J. Biol. Chem. 280 (18): 17807–14. doi:10.1074/jbc.M409479200. PMID 15757909.