VPS33A

Vacuolar protein sorting 33 homolog A (S. cerevisiae)
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4BX8​, 4BX9​
Identifiers
Symbols	VPS33A ; FLJ22395; FLJ23187
External IDs	OMIM: 610034 MGI: 1924823 HomoloGene: 11294 GeneCards: VPS33A Gene
Gene ontology Molecular function • protein binding Cellular component • lysosomal membrane • early endosome • late endosome • AP-3 adaptor complex • HOPS complex • late endosome membrane • perinuclear region of cytoplasm • clathrin complex Biological process • vesicle docking involved in exocytosis • endosome to lysosome transport • protein transport • vesicle-mediated transport • platelet formation • melanosome localization • lysosome localization • regulation of developmental pigmentation • autophagosome maturation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	65082	77573
Ensembl	ENSG00000139719	ENSMUSG00000029434
UniProt	Q96AX1	Q9D2N9
RefSeq (mRNA)	NM_022916	NM_029929
RefSeq (protein)	NP_075067	NP_084205
Location (UCSC)	Chr 12: 122.23 – 122.27 Mb	Chr 5: 123.53 – 123.57 Mb
PubMed search

Vacuolar protein sorting-associated protein 33A is a protein that in humans is encoded by the VPS33A gene.^[1][2]

Function

Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec-1 domain family, and it encodes a protein similar to the yeast class C Vps33 protein. The mammalian class C VPS proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway.^[2]

Interactions

VPS33A has been shown to interact with VPS11.^[3]

References

1. Huizing M, Didier A, Walenta J, Anikster Y, Gahl WA, Krämer H (March 2001). "Molecular cloning and characterization of human VPS18, VPS 11, VPS16, and VPS33". Gene 264 (2): 241–7. doi:10.1016/S0378-1119(01)00333-X. PMID 11250079.
2. "Entrez Gene: VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)".
3. Kim BY, Krämer H, Yamamoto A, Kominami E, Kohsaka S, Akazawa C (August 2001). "Molecular characterization of mammalian homologues of class C Vps proteins that interact with syntaxin-7". J. Biol. Chem. 276 (31): 29393–402. doi:10.1074/jbc.M101778200. PMID 11382755.

Further reading

• Pevsner J, Hsu SC, Hyde PS, Scheller RH (1997). "Mammalian homologues of yeast vacuolar protein sorting (vps) genes implicated in Golgi-to-lysosome trafficking". Gene 183 (1–2): 7–14. doi:10.1016/S0378-1119(96)00367-8. PMID 8996080.
• Kim BY, Krämer H, Yamamoto A, Kominami E, Kohsaka S, Akazawa C (2001). "Molecular characterization of mammalian homologues of class C Vps proteins that interact with syntaxin-7". J. Biol. Chem. 276 (31): 29393–402. doi:10.1074/jbc.M101778200. PMID 11382755.
• Suzuki T, Oiso N, Gautam R, Novak EK, Panthier JJ, Suprabha PG, Vida T, Swank RT, Spritz RA (2003). "The mouse organellar biogenesis mutant buff results from a mutation in Vps33a, a homologue of yeast vps33 and Drosophila carnation". Proc. Natl. Acad. Sci. U.S.A. 100 (3): 1146–50. doi:10.1073/pnas.0237292100. PMC 298741. PMID 12538872.
• Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Gissen P, Johnson CA, Gentle D, Hurst LD, Doherty AJ, O'Kane CJ, Kelly DA, Maher ER (2005). "Comparative evolutionary analysis of VPS33 homologues: genetic and functional insights". Hum. Mol. Genet. 14 (10): 1261–70. doi:10.1093/hmg/ddi137. PMID 15790593.