VPS36

Vacuolar protein sorting 36 homolog (S. cerevisiae)
PDB rendering based on 2dx5.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2HTH​, 2ZME​, 3CUQ​
Identifiers
Symbols	VPS36 ; C13orf9; CGI-145; EAP45
External IDs	OMIM: 610903 MGI: 1917410 HomoloGene: 9374 GeneCards: VPS36 Gene
Gene ontology Molecular function • protein binding • protein C-terminus binding • phosphatidylinositol-3-phosphate binding • ubiquitin binding Cellular component • ESCRT II complex • nucleus • lysosome • endosome • cytosol • late endosome membrane • extracellular exosome Biological process • transcription, DNA-templated • regulation of transcription, DNA-templated • endosomal transport • protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway • membrane organization Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	51028	70160
Ensembl	ENSG00000136100	ENSMUSG00000031479
UniProt	Q86VN1	Q91XD6
RefSeq (mRNA)	NM_001282168	NM_027338
RefSeq (protein)	NP_001269097	NP_081614
Location (UCSC)	Chr 13: 52.41 – 52.45 Mb	Chr 8: 22.19 – 22.22 Mb
PubMed search

Vacuolar protein-sorting-associated protein 36 is a protein that in humans is encoded by the VPS36 gene.^[1][2][3]

References

1. Kamura T, Burian D, Khalili H, Schmidt SL, Sato S, Liu WJ, Conrad MN, Conaway RC, Conaway JW, Shilatifard A (May 2001). "Cloning and characterization of ELL-associated proteins EAP45 and EAP20. a role for yeast EAP-like proteins in regulation of gene expression by glucose". J Biol Chem 276 (19): 16528–33. doi:10.1074/jbc.M010142200. PMID 11278625.
2. Slagsvold T, Aasland R, Hirano S, Bache KG, Raiborg C, Trambaiolo D, Wakatsuki S, Stenmark H (May 2005). "Eap45 in mammalian ESCRT-II binds ubiquitin via a phosphoinositide-interacting GLUE domain". J Biol Chem 280 (20): 19600–6. doi:10.1074/jbc.M501510200. PMID 15755741.
3. "Entrez Gene: VPS36 vacuolar protein sorting 36 homolog (S. cerevisiae)".

Further reading

• Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• von Schwedler UK, Stuchell M, Müller B, et al. (2003). "The protein network of HIV budding.". Cell 114 (6): 701–13. doi:10.1016/S0092-8674(03)00714-1. PMID 14505570.
• Martin-Serrano J, Yarovoy A, Perez-Caballero D, et al. (2003). "Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins.". Proc. Natl. Acad. Sci. U.S.A. 100 (21): 12414–9. doi:10.1073/pnas.2133846100. PMC 218772. PMID 14519844.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13.". Nature 428 (6982): 522–8. doi:10.1038/nature02379. PMC 2665288. PMID 15057823.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Bowers K, Piper SC, Edeling MA, et al. (2006). "Degradation of endocytosed epidermal growth factor and virally ubiquitinated major histocompatibility complex class I is independent of mammalian ESCRTII.". J. Biol. Chem. 281 (8): 5094–105. doi:10.1074/jbc.M508632200. PMID 16371348.
• Alam SL, Langelier C, Whitby FG, et al. (2007). "Structural basis for ubiquitin recognition by the human ESCRT-II EAP45 GLUE domain.". Nat. Struct. Mol. Biol. 13 (11): 1029–30. doi:10.1038/nsmb1160. PMID 17057716.