VPS45

Vacuolar protein sorting 45 homolog (S. cerevisiae)
Identifiers
Symbols	VPS45 ; H1; H1VPS45; SCN5; VPS45A; VPS45B; VPS54A; VSP45; VSP45A
External IDs	OMIM: 610035 MGI: 891965 HomoloGene: 5250 GeneCards: VPS45 Gene
Gene ontology Molecular function • molecular_function • protein binding Cellular component • Golgi membrane • cellular_component • Golgi apparatus • endosome membrane • integral component of membrane Biological process • intracellular protein transport • vesicle docking involved in exocytosis • blood coagulation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	11311	22365
Ensembl	ENSG00000136631	ENSMUSG00000015747
UniProt	Q9NRW7	P97390
RefSeq (mRNA)	NM_001279353	NM_013841
RefSeq (protein)	NP_001266282	NP_038869
Location (UCSC)	Chr 1: 150.07 – 150.15 Mb	Chr 3: 96 – 96.06 Mb
PubMed search

Vacuolar protein sorting-associated protein 45 is a protein that in humans is encoded by the VPS45 gene.^[1][2]

Function

Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec1 domain family, and shows a high degree of sequence similarity to mouse, rat and yeast Vps45. The exact function of this gene is not known, but its high expression in peripheral blood mononuclear cells suggests a role in trafficking proteins, including inflammatory mediators.^[2]

References

1. Pevsner J, Hsu SC, Hyde PS, Scheller RH (Feb 1997). "Mammalian homologues of yeast vacuolar protein sorting (vps) genes implicated in Golgi-to-lysosome trafficking". Gene 183 (1-2): 7–14. doi:10.1016/S0378-1119(96)00367-8. PMID 8996080.
2. "Entrez Gene: VPS45 vacuolar protein sorting 45 homolog (S. cerevisiae)".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Tellam JT, James DE, Stevens TH, Piper RC (1997). "Identification of a mammalian Golgi Sec1p-like protein, mVps45.". J. Biol. Chem. 272 (10): 6187–93. doi:10.1074/jbc.272.10.6187. PMID 9045632.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Rajasekariah P, Eyre HJ, Stanley KK, et al. (1999). "Molecular cloning and characterization of a cDNA encoding the human leucocyte vacuolar protein sorting (h1Vps45).". Int. J. Biochem. Cell Biol. 31 (6): 683–94. doi:10.1016/S1357-2725(99)00017-5. PMID 10404641.
• Nielsen E, Christoforidis S, Uttenweiler-Joseph S, et al. (2000). "Rabenosyn-5, a novel Rab5 effector, is complexed with hVPS45 and recruited to endosomes through a FYVE finger domain.". J. Cell Biol. 151 (3): 601–12. doi:10.1083/jcb.151.3.601. PMC 2185588. PMID 11062261.
• de Renzis S, Sönnichsen B, Zerial M (2002). "Divalent Rab effectors regulate the sub-compartmental organization and sorting of early endosomes.". Nat. Cell Biol. 4 (2): 124–33. doi:10.1038/ncb744. PMID 11788822.
• Dulubova I, Yamaguchi T, Gao Y, et al. (2002). "How Tlg2p/syntaxin 16 'snares' Vps45.". EMBO J. 21 (14): 3620–31. doi:10.1093/emboj/cdf381. PMC 126126. PMID 12110575.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Kim BY, Ueda M, Kominami E, et al. (2004). "Identification of mouse Vps16 and biochemical characterization of mammalian class C Vps complex.". Biochem. Biophys. Res. Commun. 311 (3): 577–82. doi:10.1016/j.bbrc.2003.10.030. PMID 14623309.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.