VTI1A

Vesicle transport through interaction with t-SNAREs 1A
PDB rendering based on 2nps.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1vcs​, 2nps​
Identifiers
Symbols	VTI1A ; MMDS3; MVti1; VTI1RP2; Vti1-rp2
External IDs	OMIM: 614316 MGI: 1855699 HomoloGene: 39963 GeneCards: VTI1A Gene
Gene ontology Molecular function • SNARE binding • SNAP receptor activity Cellular component • Golgi membrane • endosome • endoplasmic reticulum membrane • Golgi apparatus • synaptic vesicle • ER to Golgi transport vesicle membrane • integral component of membrane • clathrin-coated vesicle • SNARE complex • late endosome membrane • neuronal cell body • neuron projection terminus • perinuclear region of cytoplasm Biological process • protein targeting to vacuole • ER to Golgi vesicle-mediated transport • intra-Golgi vesicle-mediated transport • Golgi to vacuole transport • retrograde transport, endosome to Golgi • vesicle fusion with Golgi apparatus • voluntary musculoskeletal movement • Golgi ribbon formation Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	143187	53611
Ensembl	ENSG00000151532	ENSMUSG00000024983
UniProt	Q96AJ9	O89116
RefSeq (mRNA)	NM_145206	NM_001293685
RefSeq (protein)	NP_660207	NP_001280614
Location (UCSC)	Chr 10: 112.45 – 112.82 Mb	Chr 19: 55.32 – 55.63 Mb
PubMed search

Vesicle transport through interaction with t-SNAREs homolog 1A is a protein that in humans is encoded by the VTI1A gene.^[1][2]

The protein encoded by the VTI1A gene is a target-SNARE (t-SNARE) protein which is located in the membranes of target vesicle compartments.

References

1. "Entrez Gene: vesicle transport through interaction with t-SNAREs homolog 1A (yeast)".
2. Fischer von Mollard G, Stevens TH (January 1998). "A human homolog can functionally replace the yeast vesicle-associated SNARE Vti1p in two vesicle transport pathways". J. Biol. Chem. 273 (5): 2624–30. doi:10.1074/jbc.273.5.2624. PMID 9446565.

Further reading

• Luke MM, O'Meara ES, Rowland CM, et al. (2009). "Gene Variants Associated With Ischemic Stroke: The Cardiovascular Health Study". Stroke 40 (2): 363–8. doi:10.1161/STROKEAHA.108.521328. PMC 2881155. PMID 19023099.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Grupe A, Li Y, Rowland C, et al. (2006). "A Scan of Chromosome 10 Identifies a Novel Locus Showing Strong Association with Late-Onset Alzheimer Disease". Am. J. Hum. Genet. 78 (1): 78–88. doi:10.1086/498851. PMC 1380225. PMID 16385451.
• Mallard F, Tang BL, Galli T, et al. (2002). "Early/recycling endosomes-to-TGN transport involves two SNARE complexes and a Rab6 isoform". J. Cell Biol. 156 (4): 653–64. doi:10.1083/jcb.200110081. PMC 2174079. PMID 11839770.
• Shiffman D, O'Meara ES, Bare LA, et al. (2008). "Association of Gene Variants with Incident Myocardial Infarction in the Cardiovascular Health Study". Arterioscler. Thromb. Vasc. Biol. 28 (1): 173–9. doi:10.1161/ATVBAHA.107.153981. PMC 2636623. PMID 17975119.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Flowerdew SE, Burgoyne RD (2009). "A VAMP7/Vti1a SNARE complex distinguishes a non-conventional traffic route to the cell surface used by KChIP1 and Kv4 potassium channels". Biochem. J. 418 (3): 529–40. doi:10.1042/BJ20081736. PMC 2650881. PMID 19138172.
• Tai G, Lu L, Wang TL, et al. (2004). "Participation of the Syntaxin 5/Ykt6/GS28/GS15 SNARE Complex in Transport from the Early/Recycling Endosome to the Trans-Golgi Network". Mol. Biol. Cell 15 (9): 4011–22. doi:10.1091/mbc.E03-12-0876. PMC 515336. PMID 15215310.
• Antonin W, Holroyd C, Fasshauer D, et al. (2000). "A SNARE complex mediating fusion of late endosomes defines conserved properties of SNARE structure and function". EMBO J. 19 (23): 6453–64. doi:10.1093/emboj/19.23.6453. PMC 305878. PMID 11101518.