VWA2
| Von Willebrand factor A domain containing 2 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | VWA2 ; AMACO; CCSP-2; NET42 | ||||||||||||
| External IDs | MGI: 2684334 HomoloGene: 18238 GeneCards: VWA2 Gene | ||||||||||||
| |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 340706 | 240675 | |||||||||||
| Ensembl | ENSG00000165816 | ENSMUSG00000025082 | |||||||||||
| UniProt | Q5GFL6 | Q70UZ7 | |||||||||||
| RefSeq (mRNA) | NM_001272046 | NM_172840 | |||||||||||
| RefSeq (protein) | NP_001258975 | NP_766428 | |||||||||||
| Location (UCSC) |
Chr 10: 114.24 – 114.29 Mb |
Chr 19: 56.87 – 56.91 Mb | |||||||||||
| PubMed search | |||||||||||||
von Willebrand factor A domain-containing protein 2, also known as A domain-containing protein similar to matrilin and collagen (AMACO) is a protein that in humans is encoded by the VWA2 gene.[1][2]
AMACO is a member of the von Willebrand factor A-like (VWA) domain containing protein superfamily and consists of three VWA-like domains, two EGF-like domains, a cysteine-rich domain and a unique C-terminal domain.[2] AMACO is an extracellular matrix protein and mostly deposited adjacent to basement membranes.[3]
The function of this protein is not yet clear; however, it was found markedly induced in colon cancers [4] and may be useful diagnostic serum marker.
References
- ↑ "Entrez Gene: von Willebrand factor A domain containing 2".
- 1 2 Sengle G, Kobbe B, Morgelin M, Paulsson M, Wagener R (December 2003). "Identification and characterization of AMACO, a new member of the von Willebrand factor A-like domain protein superfamily with a regulated expression in the kidney". J. Biol. Chem. 278 (50): 50240–9. doi:10.1074/jbc.M307794200. PMID 14506275.
- ↑ Gebauer JM, Keene DR, Olsen BR, Sorokin LM, Paulsson M, Wagener R (August 2009). "Mouse AMACO, a kidney and skin basement membrane associated molecule that mediates RGD-dependent cell attachment". Matrix Biol. 28 (8): 456–62. doi:10.1016/j.matbio.2009.07.006. PMID 19651211.
- ↑ Xin B, Platzer P, Fink SP, Reese L, Nosrati A, Willson JK, Wilson K, Markowitz S (January 2005). "Colon cancer secreted protein-2 (CCSP-2), a novel candidate serological marker of colon neoplasia". Oncogene 24 (4): 724–31. doi:10.1038/sj.onc.1208134. PMID 15580307.
Further reading
- Eller E, Vardi P, Daly MJ, et al. (2004). "IDDM17: polymorphisms in the AMACO gene are associated with dominant protection against type 1A diabetes in a Bedouin Arab family.". Ann. N. Y. Acad. Sci. 1037 (1): 145–9. doi:10.1196/annals.1337.024. PMID 15699509.
- Gebauer JM, Müller S, Hanisch FG, et al. (2008). "O-glucosylation and O-fucosylation occur together in close proximity on the first epidermal growth factor repeat of AMACO (VWA2 protein).". J. Biol. Chem. 283 (26): 17846–54. doi:10.1074/jbc.M704820200. PMID 18434322.
External links
- VWA2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
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