Valine dehydrogenase (NADP+)

valine dehydrogenase (NADP)
Identifiers
EC number	1.4.1.8
CAS number	37255-39-3
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a valine dehydrogenase (NADP⁺) (EC 1.4.1.8) is an enzyme that catalyzes the chemical reaction

L-valine + H₂O + NADP⁺ $\rightleftharpoons$ 3-methyl-2-oxobutanoate + NH₃ + NADPH + H⁺

The 3 substrates of this enzyme are L-valine, H₂O, and NADP⁺, whereas its 4 products are 3-methyl-2-oxobutanoate, NH₃, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH₂ group of donors with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is L-valine:NADP⁺ oxidoreductase (deaminating). Other names in common use include valine dehydrogenase (nicotinanide adenine dinucleotide phosphate), and valine dehydrogenase (NADP⁺).

References

• Kagan ZS, Kretovich WL, Polyakov WA (1966). "Biosynthesis of valine by reductive amination of its keto analogue in plants". Enzymologia. 30 (6): 343–66. PMID 6005410.
• Kagan ZS, Poliakov VA, Kretovich VL (1968). "[Soluble valine dehydrogenase from roots of plant seedings]". Biokhimiia. 33 (1): 89–96. PMID 4385962.
• Kagan ZS, Poliakov VA, Kretovich VL (1969). "[Purification and properties of valine dehydrogenase]". Biokhimiia. 34 (1): 59–65. PMID 4389825.
• Behal V; Vancura, A; Volc, J; Neuzil, J; Flieger, M; Basarová, G; Bĕhal, V (1988). "Isolation and characterization of valine dehydrogenase from Streptomyces aureofaciens". J. Bacteriol. 170 (11): 5192–6. PMC 211589. PMID 3182727.