Vomilenine reductase

vomilenine reductase
Identifiers
EC number	1.5.1.32
CAS number	462127-03-3
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a vomilenine reductase (EC 1.5.1.32) is an enzyme that catalyzes the chemical reaction

1,2-dihydrovomilenine + NADP⁺ $\rightleftharpoons$ vomilenine + NADPH + H⁺

Thus, the two substrates of this enzyme are 1,2-dihydrovomilenine and NADP⁺, whereas its 3 products are vomilenine, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 1,2-dihydrovomilenine:NADP+ oxidoreductase. This enzyme participates in indole and ipecac alkaloid biosynthesis.

References

• von Schumann G, Gao S, Stockigt J (2002). "Vomilenine reductase--a novel enzyme catalyzing a crucial step in the biosynthesis of the therapeutically applied antiarrhythmic alkaloid ajmaline". Bioorg. Med. Chem. 10 (6): 1913–8. doi:10.1016/S0968-0896(01)00435-7. PMID 11937349.