WDFY3

WD repeat and FYVE domain containing 3
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3WIM​
Identifiers
Symbols	WDFY3 ; ALFY; ZFYVE25
External IDs	MGI: 1096875 HomoloGene: 22855 GeneCards: WDFY3 Gene
Gene ontology Molecular function • beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity • protein binding • 1-phosphatidylinositol binding • metal ion binding Cellular component • nuclear envelope • cytoplasm • autophagosome • endomembrane system • inclusion body • PML body • extrinsic component of membrane • nuclear membrane • Atg12-Atg5-Atg16 complex • extrinsic component of autophagosome membrane Biological process • endosomal transport • positive regulation of macroautophagy • aggrephagy Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23001	72145
Ensembl	ENSG00000163625	ENSMUSG00000043940
UniProt	Q8IZQ1	Q6VNB8
RefSeq (mRNA)	NM_014991	NM_172882
RefSeq (protein)	NP_055806	NP_766470
Location (UCSC)	Chr 4: 84.67 – 84.97 Mb	Chr 5: 101.83 – 102.07 Mb
PubMed search

WD repeat and FYVE domain-containing protein 3 is a protein that in humans is encoded by the WDFY3 gene.^[1][2]

This gene encodes a protein which contains WD repeats and an FYVE domain. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined.^[2]

References

1. Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Jul 1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032.
2. "Entrez Gene: WDFY3 WD repeat and FYVE domain containing 3".

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• "Toward a complete human genome sequence.". Genome Res. 8 (11): 1097–108. 1999. doi:10.1101/gr.8.11.1097. PMID 9847074.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Simonsen A, Birkeland HC, Gillooly DJ, et al. (2005). "Alfy, a novel FYVE-domain-containing protein associated with protein granules and autophagic membranes.". J. Cell. Sci. 117 (Pt 18): 4239–51. doi:10.1242/jcs.01287. PMID 15292400.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.