WDR57

Small nuclear ribonucleoprotein 40kDa (U5)
Identifiers
Symbols	SNRNP40 ; 40K; HPRP8BP; PRP8BP; PRPF8BP; SPF38; WDR57
External IDs	OMIM: 607797 HomoloGene: 3538 GeneCards: SNRNP40 Gene
Gene ontology Molecular function • protein binding • poly(A) RNA binding Cellular component • nucleoplasm • U5 snRNP • small nucleolar ribonucleoprotein complex • cytoplasm • precatalytic spliceosome • catalytic step 2 spliceosome Biological process • RNA splicing, via transesterification reactions • mRNA splicing, via spliceosome • RNA processing • RNA splicing • gene expression Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9410	66585
Ensembl	ENSG00000060688	ENSMUSG00000074088
UniProt	Q96DI7	Q6PE01
RefSeq (mRNA)	NM_004814	NM_025645
RefSeq (protein)	NP_004805	NP_079921
Location (UCSC)	Chr 1: 31.26 – 31.3 Mb	Chr 4: 130.36 – 130.39 Mb
PubMed search

WD repeat domain 57 (U5 snRNP specific), also known as WDR57, is a gene found in many organisms, including, but not limited to Homo sapiens, Gallus gallus, Pan troglodytes, Canus familiaris, Bos taurus, Mus musculus, and Rattus norvegicus.^[1]

Function

This gene encodes a component of the U5 small nuclear ribonucleoprotein (snRNP) particle. The U5 snRNP is part of the spliceosome, a multiprotein complex that catalyzes the removal of introns from pre-messenger RNAs.^[1]

Interactions

WDR57 has been shown to interact with PRPF8^[2][3] and EFTUD2.^[2][3]

References

1. "Entrez Gene: WDR57 WD repeat domain 57 (U5 snRNP specific)".
2. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
3. Achsel T, Ahrens K, Brahms H, Teigelkamp S, Lührmann R (Nov 1998). "The human U5-220kD protein (hPrp8) forms a stable RNA-free complex with several U5-specific proteins, including an RNA unwindase, a homologue of ribosomal elongation factor EF-2, and a novel WD-40 protein". Molecular and Cellular Biology 18 (11): 6756–66. doi:10.1128/mcb.18.11.6756. PMC 109259. PMID 9774689.

Further reading

• Turner IA, Norman CM, Churcher MJ, Newman AJ (Dec 2004). "Roles of the U5 snRNP in spliceosome dynamics and catalysis". Biochemical Society Transactions 32 (Pt 6): 928–31. doi:10.1042/BST0320928. PMID 15506927.
• Neubauer G, King A, Rappsilber J, Calvio C, Watson M, Ajuh P, Sleeman J, Lamond A, Mann M (Sep 1998). "Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex". Nature Genetics 20 (1): 46–50. doi:10.1038/1700. PMID 9731529.
• Achsel T, Ahrens K, Brahms H, Teigelkamp S, Lührmann R (Nov 1998). "The human U5-220kD protein (hPrp8) forms a stable RNA-free complex with several U5-specific proteins, including an RNA unwindase, a homologue of ribosomal elongation factor EF-2, and a novel WD-40 protein". Molecular and Cellular Biology 18 (11): 6756–66. doi:10.1128/mcb.18.11.6756. PMC 109259. PMID 9774689.
• Makarov EM, Makarova OV, Achsel T, Lührmann R (May 2000). "The human homologue of the yeast splicing factor prp6p contains multiple TPR elements and is stably associated with the U5 snRNP via protein-protein interactions". Journal of Molecular Biology 298 (4): 567–75. doi:10.1006/jmbi.2000.3685. PMID 10788320.
• Jurica MS, Licklider LJ, Gygi SR, Grigorieff N, Moore MJ (Apr 2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC 1370266. PMID 11991638.
• Jordanova A, Irobi J, Thomas FP, Van Dijck P, Meerschaert K, Dewil M, Dierick I, Jacobs A, De Vriendt E, Guergueltcheva V, Rao CV, Tournev I, Gondim FA, D'Hooghe M, Van Gerwen V, Callaerts P, Van Den Bosch L, Timmermans JP, Robberecht W, Gettemans J, Thevelein JM, De Jonghe P, Kremensky I, Timmerman V (Feb 2006). "Disrupted function and axonal distribution of mutant tyrosyl-tRNA synthetase in dominant intermediate Charcot-Marie-Tooth neuropathy". Nature Genetics 38 (2): 197–202. doi:10.1038/ng1727. PMID 16429158.
• Liu S, Rauhut R, Vornlocher HP, Lührmann R (Jul 2006). "The network of protein-protein interactions within the human U4/U6.U5 tri-snRNP". RNA 12 (7): 1418–30. doi:10.1261/rna.55406. PMC 1484429. PMID 16723661.
• Higa LA, Wu M, Ye T, Kobayashi R, Sun H, Zhang H (Nov 2006). "CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation". Nature Cell Biology 8 (11): 1277–83. doi:10.1038/ncb1490. PMID 17041588.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.