WD repeat-containing protein 77

WD repeat domain 77
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4GQB​, 4X60​, 4X61​, 4X63​
Identifiers
Symbols	WDR77 ; HKMT1069; MEP-50; MEP50; Nbla10071; p44; p44/Mep50
External IDs	OMIM: 611734 MGI: 1917715 HomoloGene: 11466 GeneCards: WDR77 Gene
Gene ontology Molecular function • protein binding • ligand-dependent nuclear receptor transcription coactivator activity Cellular component • nucleus • nucleoplasm • cytoplasm • Golgi apparatus • cytosol • methylosome Biological process • spliceosomal snRNP assembly • chromatin organization • regulation of transcription from RNA polymerase II promoter • positive regulation of cell proliferation • gene expression • ncRNA metabolic process • secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development • negative regulation of epithelial cell proliferation involved in prostate gland development Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	79084	70465
Ensembl	ENSG00000116455	ENSMUSG00000000561
UniProt	Q9BQA1	Q99J09
RefSeq (mRNA)	NM_024102	NM_027432
RefSeq (protein)	NP_077007	NP_081708
Location (UCSC)	Chr 1: 111.44 – 111.45 Mb	Chr 3: 105.96 – 105.97 Mb
PubMed search

Methylosome protein 50 is a protein that in humans is encoded by the WDR77 gene.^[1][2][3]

Interactions

WD repeat-containing protein 77 has been shown to interact with CTDP1^[4] and Protein arginine methyltransferase 5.^[1]

References

1. Friesen WJ, Wyce A, Paushkin S, Abel L, Rappsilber J, Mann M, Dreyfuss G (Mar 2002). "A novel WD repeat protein component of the methylosome binds Sm proteins". J Biol Chem 277 (10): 8243–7. doi:10.1074/jbc.M109984200. PMID 11756452.
2. Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Jun 1996). "A "double adaptor" method for improved shotgun library construction". Anal Biochem 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
3. "Entrez Gene: WDR77 WD repeat domain 77".
4. Licciardo, Paolo; Amente Stefano; Ruggiero Luca; Monti Maria; Pucci Piero; Lania Luigi; Majello Barbara (Feb 2003). "The FCP1 phosphatase interacts with RNA polymerase II and with MEP50 a component of the methylosome complex involved in the assembly of snRNP". Nucleic Acids Res. (England) 31 (3): 999–1005. doi:10.1093/nar/gkg197. PMC 149217. PMID 12560496.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Licciardo P, Amente S, Ruggiero L, et al. (2003). "The FCP1 phosphatase interacts with RNA polymerase II and with MEP50 a component of the methylosome complex involved in the assembly of snRNP.". Nucleic Acids Res. 31 (3): 999–1005. doi:10.1093/nar/gkg197. PMC 149217. PMID 12560496.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Yamada S, Ohira M, Horie H, et al. (2004). "Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas.". Oncogene 23 (35): 5901–11. doi:10.1038/sj.onc.1207782. PMID 15221005.
• Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Amente S, Napolitano G, Licciardo P, et al. (2005). "Identification of proteins interacting with the RNAPII FCP1 phosphatase: FCP1 forms a complex with arginine methyltransferase PRMT5 and it is a substrate for PRMT5-mediated methylation.". FEBS Lett. 579 (3): 683–9. doi:10.1016/j.febslet.2004.12.045. PMID 15670829.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
• Furuno K, Masatsugu T, Sonoda M, et al. (2006). "Association of Polycomb group SUZ12 with WD-repeat protein MEP50 that binds to histone H2A selectively in vitro.". Biochem. Biophys. Res. Commun. 345 (3): 1051–8. doi:10.1016/j.bbrc.2006.05.014. PMID 16712789.
• Zhou L, Wu H, Lee P, Wang Z (2007). "Roles of the androgen receptor cofactor p44 in the growth of prostate epithelial cells.". J. Mol. Endocrinol. 37 (2): 283–300. doi:10.1677/jme.1.02062. PMID 17032745.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Liang JJ, Wang Z, Chiriboga L, et al. (2007). "The expression and function of androgen receptor coactivator p44 and protein arginine methyltransferase 5 in the developing testis and testicular tumors.". J. Urol. 177 (5): 1918–22. doi:10.1016/j.juro.2007.01.017. PMID 17437848.