WDR8
| WD repeat containing, antisense to TP73 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbols | WRAP73 ; WDR8 | ||||||||||
| External IDs | OMIM: 606040 MGI: 1891749 HomoloGene: 9857 GeneCards: WRAP73 Gene | ||||||||||
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| RNA expression pattern | |||||||||||
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| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | 49856 | 59002 | |||||||||
| Ensembl | ENSG00000116213 | ENSMUSG00000029029 | |||||||||
| UniProt | Q9P2S5 | Q9JM98 | |||||||||
| RefSeq (mRNA) | NM_017818 | NM_021499 | |||||||||
| RefSeq (protein) | NP_060288 | NP_067474 | |||||||||
| Location (UCSC) |
Chr 1: 3.63 – 3.65 Mb |
Chr 4: 154.14 – 154.17 Mb | |||||||||
| PubMed search | |||||||||||
WD repeat-containing protein 8 is a protein that in humans is encoded by the WDR8 gene.[1]
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This family member is 89% identical to the mouse Wdr8 protein at the amino acid level. The function of this protein is not known, and the mouse studies suggest that the Wdr8 protein may play a role in the process of ossification.[1]
References
Further reading
- Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
- Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature 441 (7091): 315–321. doi:10.1038/nature04727. PMID 16710414.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Koshizuka Y, Ikegawa S, Sano M, et al. (2001). "Isolation, characterization, and mapping of the mouse and human WDR8 genes, members of a novel WD-repeat gene family". Genomics 72 (3): 252–259. doi:10.1006/geno.2000.6475. PMID 11401440.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
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