WFIKKN1

WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1
PDB rendering based on 2ddi.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2DDI​, 2DDJ​
Identifiers
Symbols	WFIKKN1 ; C16orf12; RJD2; WFDC20A; WFIKKN
External IDs	OMIM: 608021 MGI: 2670967 HomoloGene: 14244 GeneCards: WFIKKN1 Gene
Gene ontology Molecular function • serine-type endopeptidase inhibitor activity • protein binding • metalloendopeptidase inhibitor activity Cellular component • extracellular region Biological process • skeletal system development • negative regulation of endopeptidase activity • negative regulation of protein binding • negative regulation of DNA binding • muscle fiber development • palate development Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	117166	215001
Ensembl	ENSG00000127578	ENSMUSG00000071192
UniProt	Q96NZ8	Q8R0S6
RefSeq (mRNA)	NM_053284	NM_001100454
RefSeq (protein)	NP_444514	NP_001093924
Location (UCSC)	Chr 16: 0.63 – 0.63 Mb	Chr 17: 25.88 – 25.88 Mb
PubMed search

WAP, kazal, immunoglobulin, kunitz and NTR domain-containing protein 1 is a protein that is encoded by the WFIKKN1 gene.^[1][2][3] when found in humans.

This gene encodes a secreted multidomain protein consisting of a signal peptide, a WAP domain, a follistatin domain, an immunoglobulin domain, two tandem Kunitz domains, and an NTR domain. These domains have been implicated frequently in inhibition of various types of proteases, suggesting that the encoded protein may be a multivalent protease inhibitor and may control the action of multiple types of serine proteases as well as metalloproteinases.^[3]

References

1. Trexler M, Banyai L, Patthy L (Mar 2001). "A human protein containing multiple types of protease-inhibitory modules". Proc Natl Acad Sci U S A 98 (7): 3705–9. doi:10.1073/pnas.061028398. PMC 31116. PMID 11274388.
2. Trexler M, Banyai L, Patthy L (Apr 2002). "Distinct expression pattern of two related human proteins containing multiple types of protease-inhibitory modules". Biol Chem 383 (1): 223–8. doi:10.1515/BC.2002.023. PMID 11928817.
3. "Entrez Gene: WFIKKN1 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1".

Further reading

• Liepinsh E, Nagy A, Trexler M, et al. (2006). "Second Kunitz-type protease inhibitor domain of the human WFIKKN1 protein". J. Biomol. NMR 35 (1): 73–8. doi:10.1007/s10858-006-9013-1. PMID 16791741.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
• Nagy A, Trexler M, Patthy L (2003). "Expression, purification and characterization of the second Kunitz-type protease inhibitor domain of the human WFIKKN protein". Eur. J. Biochem. 270 (9): 2101–7. doi:10.1046/j.1432-1033.2003.03593.x. PMID 12709070.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Daniels RJ, Peden JF, Lloyd C, et al. (2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16". Hum. Mol. Genet. 10 (4): 339–52. doi:10.1093/hmg/10.4.339. PMID 11157797.