WHSC2

Negative elongation factor complex member A
Identifiers
Symbols NELFA ; NELF-A; P/OKcl.15; WHSC2
External IDs OMIM: 606026 MGI: 1346098 HomoloGene: 68478 GeneCards: NELFA Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 7469 24116
Ensembl ENSG00000185049 ENSMUSG00000029111
UniProt Q9H3P2 Q8BG30
RefSeq (mRNA) NM_005663 NM_011914
RefSeq (protein) NP_005654 NP_036044
Location (UCSC) Chr 4:
1.98 – 2.04 Mb
Chr 5:
33.9 – 33.94 Mb
PubMed search

Negative elongation factor A is a protein that in humans is encoded by the WHSC2 gene.[1][2]

Function

This gene is expressed ubiquitously with higher levels in fetal than in adult tissues. It encodes a protein sharing 93% sequence identity with the mouse protein. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encoded protein is found to be capable of reacting with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients. This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation.[2] WHSC2 encodes the NELF-A subunit of the NELF complex.[3]

Interactions

WHSC2 has been shown to interact with RDBP.[4]

References

  1. Wright TJ, Costa JL, Naranjo C, Francis-West P, Altherr MR (Jul 1999). "Comparative analysis of a novel gene from the Wolf-Hirschhorn/Pitt-Rogers-Danks syndrome critical region". Genomics 59 (2): 203–12. doi:10.1006/geno.1999.5871. PMID 10409432.
  2. 1 2 "Entrez Gene: WHSC2 Wolf-Hirschhorn syndrome candidate 2".
  3. Narita T, Yamaguchi Y, Yano K, Sugimoto S, Chanarat S, Wada T, Kim DK, Hasegawa J, Omori M, Inukai N, Endoh M, Yamada T, Handa H (Mar 2003). "Human transcription elongation factor NELF: identification of novel subunits and reconstitution of the functionally active complex". Molecular and Cellular Biology 23 (6): 1863–73. doi:10.1128/MCB.23.6.1863-1873.2003. PMC 149481. PMID 12612062.
  4. Narita T, Yamaguchi Y, Yano K, Sugimoto S, Chanarat S, Wada T, Kim DK, Hasegawa J, Omori M, Inukai N, Endoh M, Yamada T, Handa H (Mar 2003). "Human transcription elongation factor NELF: identification of novel subunits and reconstitution of the functionally active complex". Molecular and Cellular Biology 23 (6): 1863–73. doi:10.1128/MCB.23.6.1863-1873.2003. PMC 149481. PMID 12612062.

Further reading

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