Warthin–Finkeldey cell

A Warthin–Finkeldey cell is a type of giant multinucleate cell found in hyperplastic lymph nodes early in the course of measles and also in HIV-infected individuals,^[1] as well as in Kimura disease,^[2] and more rarely in a number of neoplastic (e.g. lymphoma) and non-neoplastic lymph node disorders.^[3] Their origin is uncertain, but they have previously been shown to stain with markers similar to those of follicular dendritic cells, including CD21.^[4] Under the light microscope, these cells consist of a large, grape-like cluster of nuclei.

References

1. Burke AP, Anderson D, Mannan P, Ribas JL, Liang YH, Smialek J, Virmani R. (1994). "Systemic lymphadenopathic histology in human immunodeficiency virus-1-seropositive drug addicts without apparent acquired immunodeficiency syndrome". Hum Pathol. 25 (3): 248–56. doi:10.1016/0046-8177(94)90196-1. PMID 8150456.
2. Abuel-Haija M, Hurford MT (2007). "Kimura Disease". Archives of Pathology & Laboratory Medicine 131 (4): 650–651. doi:10.1043/1543-2165(2007)131[650:KD]2.0.CO;2. PMID 17425383.
3. Kjeldsberg CR, Kim H. (1981). "Polykaryocytes resembling Warthin-Finkeldey giant cells in reactive and neoplastic lymphoid disorders.". Hum Pathol. 12 (3): 267–72. doi:10.1016/S0046-8177(81)80128-1. PMID 7228021.
4. Orenstein JM (1988). "The Warthin-Finkeldey-Type Giant Cell in HIV Infection, What Is It?". Ultrastructural Pathology 22: 293–303. doi:10.3109/01913129809103350.