William Castle (disambiguation)
William Castle may refer to:
- William Castle (1914–1977), American film director, producer, and actor
- William B. Castle (1814–1872), American politician from Ohio
- William Bosworth Castle (1897–1990), American physician and physiologist
- William Ernest Castle (1867–1962), American geneticist
- William Richards Castle (1849–1935), lawyer, politician and Attorney General of Hawaii
- William Richards Castle, Jr. (1878–1963), U.S. educator, diplomat and ambassador to Japan
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