William Paine
William Paine may refer to:
- William Paine (physician) (1750–1833), Canadian physician and political figure
- William A. Paine (1855–1929), American businessman
- William W. Paine (1817–1882), U.S. Representative from Georgia
- See also
- William Hacket Pain (1855–1924), British Army officer
- William Payne (disambiguation)
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