XAB2

XPA binding protein 2

Identifiers

XAB2 ; HCNP; HCRN; NTC90; SYF1

External IDs

OMIM: 610850 MGI: 1914689 HomoloGene: 5738 GeneCards: XAB2 Gene

Gene ontology
Molecular function	• protein binding
Cellular component	• Prp19 complex • nucleus • nucleoplasm • membrane • prespliceosome • catalytic step 1 spliceosome • catalytic step 2 spliceosome • post-mRNA release spliceosomal complex
Biological process	• generation of catalytic spliceosome for first transesterification step • mRNA splicing, via spliceosome • blastocyst development • DNA repair • transcription-coupled nucleotide-excision repair • nucleotide-excision repair • transcription, DNA-templated
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000076924

ENSMUSG00000019470

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 19:
7.62 – 7.63 Mb

Chr 8:
3.61 – 3.62 Mb

PubMed search

Pre-mRNA-splicing factor SYF1 is a protein that in humans is encoded by the XAB2 gene.^[1]^[2]

Interactions

XAB2 has been shown to interact with ERCC8^[1] and XPA.^[1]

References

1 2 3 Nakatsu Y, Asahina H, Citterio E, Rademakers S, Vermeulen W, Kamiuchi S, Yeo JP, Khaw MC, Saijo M, Kodo N, Matsuda T, Hoeijmakers JH, Tanaka K (Nov 2000). "XAB2, a novel tetratricopeptide repeat protein involved in transcription-coupled DNA repair and transcription". J. Biol. Chem. 275 (45): 34931–7. doi:10.1074/jbc.M004936200. PMID 10944529.
↑ "Entrez Gene: XAB2 XPA binding protein 2".

Further reading

Hirosawa M, Nagase T, Ishikawa K, Kikuno R, Nomura N, Ohara O (1999). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain". DNA Res. 6 (5): 329–36. doi:10.1093/dnares/6.5.329. PMID 10574461.
Jurica MS, Licklider LJ, Gygi SR, Grigorieff N, Moore MJ (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC 1370266. PMID 11991638.
Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Wan D, Gong Y, Qin W, Zhang P, Li J, Wei L, Zhou X, Li H, Qiu X, Zhong F, He L, Yu J, Yao G, Jiang H, Qian L, Yu Y, Shu H, Chen X, Xu H, Guo M, Pan Z, Chen Y, Ge C, Yang S, Gu J (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.

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