XIRP2

Xin actin binding repeat containing 2
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4F14​
Identifiers
Symbols	XIRP2 ; CMYA3
External IDs	OMIM: 609778 MGI: 2685198 HomoloGene: 19388 GeneCards: XIRP2 Gene
Gene ontology Molecular function • actin binding • alpha-actinin binding Cellular component • Z disc • cell junction Biological process • ventricular septum development • actin cytoskeleton organization • cell-cell junction organization • cardiac muscle tissue morphogenesis Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	129446	241431
Ensembl	ENSG00000163092	ENSMUSG00000027022
UniProt	A4UGR9	Q4U4S6
RefSeq (mRNA)	NM_001079810	NM_001024618
RefSeq (protein)	NP_001073278	NP_001019789
Location (UCSC)	Chr 2: 166.89 – 167.26 Mb	Chr 2: 67.45 – 67.53 Mb
PubMed search

Xin actin-binding repeat-containing protein 2 is a protein that in humans is encoded by the XIRP2 gene.^[1][2][3][4]

References

1. Huang HT, Brand OM, Mathew M, Ignatiou C, Ewen EP, McCalmon SA, Naya FJ (Dec 2006). "Myomaxin is a novel transcriptional target of MEF2A that encodes a Xin-related alpha-actinin-interacting protein". J Biol Chem 281 (51): 39370–9. doi:10.1074/jbc.M603244200. PMID 17046827.
2. Sinn HW, Balsamo J, Lilien J, Lin JJ (Aug 2002). "Localization of the novel Xin protein to the adherens junction complex in cardiac and skeletal muscle during development". Dev Dyn 225 (1): 1–13. doi:10.1002/dvdy.10131. PMID 12203715.
3. Pacholsky D, Vakeel P, Himmel M, Lowe T, Stradal T, Rottner K, Furst DO, van der Ven PF (Oct 2004). "Xin repeats define a novel actin-binding motif". J Cell Sci 117 (Pt 22): 5257–68. doi:10.1242/jcs.01406. PMID 15454575.
4. "Entrez Gene: CMYA3 cardiomyopathy associated 3".

Further reading

• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Blasi F, Bacchelli E, Carone S, et al. (2006). "SLC25A12 and CMYA3 gene variants are not associated with autism in the IMGSAC multiplex family sample.". Eur. J. Hum. Genet. 14 (1): 123–6. doi:10.1038/sj.ejhg.5201444. PMID 16205742.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Pan PW, Li K, Tuggle CK, et al. (2004). "Sequencing, tissue distribution and physical mapping of the porcine homologue of cardiomyopathy associated 3 (CMYA3).". Anim. Genet. 34 (6): 473–4. doi:10.1046/j.0268-9146.2003.01059.x. PMID 14687087.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.