Yapsin 1

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Yapsin 1 (EC 3.4.23.41, yeast aspartic protease 3, Yap3 gene product (Saccharomyces cerevisiae)) is an enzyme.^[1]^[2]^[3] This enzyme catalyses the following chemical reaction

Hydrolyses various precursor proteins with Arg or Lys in P1, and commonly Arg or Lys also in P2. The P3 amino acid is usually non-polar, but otherwise additional basic amino acids are favourable in both non-prime and prime positions

This enzyme belongs to the peptidase family A1 of pepsin.

References

↑ Cawley, N.X., Chen, H.C., Beinfeld, M.C. and Loh, Y.P. (1996). "Specificity and kinetic studies on the cleavage of various prohormone mono- and paired-basic residue sites by yeast aspartic protease 3". J. Biol. Chem. 271: 4168–4176. doi:10.1074/jbc.271.8.4168. PMID 8626758.
↑ Fuller, R.S. (1998). "Yapsin 2". In Barrett, A.J., Rawlings, N.D. and Woessner, J.F. Handbook of Proteolytic Enzymes. London: Academic Press. pp. 908–909.
↑ Olsen, V., Guruprasad, K., Cawley, N.X., Chen, H.C., Blundell, T.L. and Loh, Y.P. (1998). "Cleavage efficiency of the novel aspartic protease yapsin 1 (Yap3p) enhanced for substrates with arginine residues flanking the P1 site: correlation with electronegative active-site pockets predicted by molecular modeling". Biochemistry 37: 2768–2777. doi:10.1021/bi9724826. PMID 9485427.

External links

Yapsin 1 at the US National Library of Medicine Medical Subject Headings (MeSH)

Proteases: aspartate proteases (EC 3.4.23)

Vertebrate	Pepsin Chymosin Renin Signal peptide peptidase Beta secretase 1 2

Pathogenic	Plasmepsin HIV-1 protease

Plant	Nepenthesin

Cathepsin	D E

Proteins: enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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