Yvonne Connolly Martin

Yvonne Connolly Martin (born September 13, 1936) is an American cheminformatics and computer-aided drug design expert who rose to the rank of Senior Volwiler Research Fellow at Abbott Laboratories (now AbbVie). Trained in chemistry at Northwestern University, she became a leader in collaborative science aimed at discovering and developing bioactive molecules as therapeutic agents, with her contributions proceeding from application of methods to understand how descriptors of molecular shapes and physicochemical properties relate to their biological activity.[1] She is the author of a seminal volume in cheminformatics, Quantitative Drug Design (2nd Ed., 2010), and has been the recipient of numerous awards in her field, including being named as a Fellow of the American Association for the Advancement of Science (1985) and of the International Union of Pure and Applied Chemistry (2000), and receiving the Herman Skolnik Award from the American Chemical Society (2013).


Early life and education

Yvonne Connolly was born to Irene and Elvert Connolly in 1936. She is married to William Brady Martin and has two children.[2][3]

Martin received a Bachelor's degree in 1958 from Carleton College, Northfield, Minnesota. She was the only woman to be a chemistry/zoology major in her year.[2] From 1958 to 1960 she worked as a pharmacology assistant at Abbott Labs. She was awarded a predoctoral fellowship from the National Science Foundation for the years 1960-1963, attending Northwestern University, Evanston, Illinois.[2] She received her Ph.D. in physical biochemistry from Northwestern University in 1964.[4] From 1967 to 1968, she spent a sabbatical year working with QSAR pioneer Corwin Hansch at Pomona College.[5] She then returned to Abbott Labs.[2]

Career

External video
“Tautomers: A Rant”, Yvonne Martin, 2009, ChemAxon

Martin's career with Abbott Laboratories has extended over forty years. Martin formally retired as a Senior Research Fellow in 2006, but has continued to be associated with Abbott Laboratories on a contract basis, working on topics in which she is interested.[2] She has also taught as a visiting professor at the University of Virginia.[2]

Martin's work with Corwin Hansch led to her ongoing work in QSAR,[6] using computers to develop both 2D and 3D models capturing the chemical and biological properties of molecules. As an early proponent of computational chemistry and its use in drug design, she developed combinatorial chemistry and molecular graphics techniques and was involved in the development of software packages for pharmacophore analysis such as DISCO[7][8] and ALADDIN.[9][10] Her work has directly affected modern day drug discovery and supported the computer design of novel compounds.[1][9] Martin has particularly focused on identifying properties of molecules relevant to biological activity,[2] including their potency, binding affinity, and ADME properties.[1] Her methods have been applied to the study of diseases including hypertension, Parkinson’s disease, ulcers, bacterial infections, arthritis, and angina.[2]

She has significantly contributed to the development of compound collections and combinatorial libraries which investigators can use to develop and compare measures of molecular similarity and diversity. Her collection of MAO (monoamine oxidase) inhibitors has been widely used by researchers.[1]

In 1989 Martin helped to found the International Quantitative Structure Activity Relationship & Modeling Society (now called the Cheminformatics and QSAR Society). She served as a board member and was chair of the organization from 2001 to 2005.[2][5]

In addition to more than a hundred scholarly publications, she has written or edited six books.[2] These include her textbook on Quantitative Drug Design.[11] Editorially, she has worked on Perspectives in Drug Design and Discovery, QSAR: Annual Reports in Computational Chemistry, Journal of Computer-Aided Drug Design and QSAR & Combinatorial Science.[1] She has registered eight patents.[2] She is listed in the World directory of crystallographers : and of other scientists employing crystallographic methods.[4]

Awards and honors

References

  1. 1 2 3 4 5 6 "2005 SBS Accomplishment award to Martin". The Cheminformatics and QSAR Society. October 14, 2005. Retrieved 27 January 2016.
  2. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 Gardner, Catie. "2013 Alumni Association Award Recipients". Carleton Alumni Network. Retrieved 27 January 2016.
  3. ↑ "Yvonne Connolly Martin '58 and her husband Bill find seats during Friday's Heywood Society Luncheon". Carleton Alumni Network. Retrieved 27 January 2016.
  4. 1 2 Epelboin, Yves (1995). World directory of crystallographers : and of other scientists employing crystallographic methods (9th ed.). Dordrecht: Kluwer Academic. p. 235. ISBN 079233180X. Retrieved 27 January 2016.
  5. 1 2 3 Grethe, Guenter. "2009 Herman Skolnik Award Winner Announced". American Chemical Society. Retrieved 27 January 2016.
  6. ↑ Martin, Yvonne Connolly (May 2012). "Hansch analysis 50 years on". Wiley Interdisciplinary Reviews: Computational Molecular Science 2 (3): 435–442. doi:10.1002/wcms.1096. Retrieved 28 January 2016.
  7. ↑ Merz, Jr., Kenneth M.; Ringe, Dagmar; Reynolds, Charles H. (2010). Drug design : structure- and ligand-based approaches (1st ed.). Cambridge [U.K.]: Cambridge University Press. p. 138. ISBN 9780521887236. Retrieved 28 January 2016.
  8. ↑ Güner, Osman F. (1999). Pharmacophore perception, development, and use in drug design. LaJolla, CA: International University Line. pp. 16, 49–68. ISBN 0-9636817-6-1. Retrieved 28 January 2016.
  9. 1 2 3 "Honorary Members of the MGMS Community". Molecular Graphics and Modelling Society. Retrieved 27 January 2016.
  10. ↑ Van Drie, John H.; Weininger, David; Martin, Yvonne C. (September 1989). "ALADDIN: An integrated tool for computer-assisted molecular design and pharmacophore recognition from geometric, steric, and substructure searching of three-dimensional molecular structures". Journal of Computer-Aided Molecular Design 3 (3): 225–251. doi:10.1007/BF01533070. Retrieved 28 January 2016.
  11. ↑ Martin, Yvonne Connolly (2010). Quantitative drug design : a critical introduction (2nd ed.). Boca Raton: CRC Press/Taylor & Francis. ISBN 9781420070996.
  12. ↑ Stouch, Terry Richard (11 December 2009). "A well deserved honor: Yvonne Martin, 2009 recipient of the Herman Skolnik Award". Journal of Computer-Aided Molecular Design 23 (12): 829–830. doi:10.1007/s10822-009-9311-2. Retrieved 27 January 2016.
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