ZBP1

Z-DNA binding protein 1
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols ZBP1 ; C20orf183; DAI; DLM-1; DLM1
External IDs OMIM: 606750 MGI: 1927449 HomoloGene: 10972 GeneCards: ZBP1 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 81030 58203
Ensembl ENSG00000124256 ENSMUSG00000027514
UniProt Q9H171 Q9QY24
RefSeq (mRNA) NM_001160417 NM_001139519
RefSeq (protein) NP_001153889 NP_001132991
Location (UCSC) Chr 20:
57.6 – 57.62 Mb		 Chr 2:
173.21 – 173.22 Mb
PubMed search

Z-DNA-binding protein 1, also known as DNA-dependent activator of IFN-regulatory factors (DAI) and DLM-1, is a protein that in humans is encoded by the ZBP1 gene.[1][2]

ZBP1 is also an abbreviation for chicken or rat β-actin zipcode-binding protein 1, a homolog of the human insulin-like growth factor 2 mRNA-binding protein 1 (IMP-1) and murine CRD-BP, the proteins involved in mRNA transport (RNA-binding proteins, RBPs).

Function

DLM1 encodes a Z-DNA binding protein. Z-DNA formation is a dynamic process, largely controlled by the amount of supercoiling.[2] ZBP1 recognizes DNA in the cytoplasm as an antiviral mechanism. Viral life cycles often include steps where DNA is exposed in the cytoplasm. DNA is normally contained in the nucleus of a cell, and therefore cells use proteins like ZBP1 as an indicator of a viral infection. Once ZBP1 is activated, it increases the production of antiviral cytokines such as interferon beta.[3] DLM1 then binds to cytosolic Viral DNA using two Z-DNA-binding domains (Zα and Zβ) at its N-terminus along with a DNA binding domain (D3).[4]

Zipcode binding protein 1 (ZBP1) was shown to regulate dendritogenesis (dendrite formation) in hippocampal neurons.[5]

References

  1. ↑ Rothenburg S, Schwartz T, Koch-Nolte F, Haag F (Feb 2002). "Complex regulation of the human gene for the Z-DNA binding protein DLM-1". Nucleic Acids Research 30 (4): 993–1000. doi:10.1093/nar/30.4.993. PMC 100341. PMID 11842111.
  2. 1 2 "Entrez Gene: ZBP1 Z-DNA binding protein 1".
  3. ↑ Rathinam VA, Fitzgerald KA (Mar 2011). "Innate immune sensing of DNA viruses". Virology 411 (2): 153–62. doi:10.1016/j.virol.2011.02.003. PMC 3070751. PMID 21334037.
  4. ↑ Ha SC, Kim D, Hwang HY, Rich A, Kim YG, Kim KK (Dec 2008). "The crystal structure of the second Z-DNA binding domain of human DAI (ZBP1) in complex with Z-DNA reveals an unusual binding mode to Z-DNA". Proceedings of the National Academy of Sciences of the United States of America 105 (52): 20671–6. doi:10.1073/pnas.0810463106. PMID 19095800.
  5. ↑ Perycz M, Urbanska AS, Krawczyk PS, Parobczak K, Jaworski J (Apr 2011). "Zipcode binding protein 1 regulates the development of dendritic arbors in hippocampal neurons". The Journal of Neuroscience 31 (14): 5271–85. doi:10.1523/JNEUROSCI.2387-10.2011. PMID 21471362.

Further reading

  • Ha SC, Van Quyen D, Hwang HY, Oh DB, Brown BA, Lee SM, Park HJ, Ahn JH, Kim KK, Kim YG (Feb 2006). "Biochemical characterization and preliminary X-ray crystallographic study of the domains of human ZBP1 bound to left-handed Z-DNA". Biochimica et Biophysica Acta 1764 (2): 320–3. doi:10.1016/j.bbapap.2005.12.012. PMID 16448869. 
  • Schwartz T, Behlke J, Lowenhaupt K, Heinemann U, Rich A (Sep 2001). "Structure of the DLM-1-Z-DNA complex reveals a conserved family of Z-DNA-binding proteins". Nature Structural Biology 8 (9): 761–5. doi:10.1038/nsb0901-761. PMID 11524677. 
  • Schwartz T, Rould MA, Lowenhaupt K, Herbert A, Rich A (Jun 1999). "Crystal structure of the Zalpha domain of the human editing enzyme ADAR1 bound to left-handed Z-DNA". Science 284 (5421): 1841–5. doi:10.1126/science.284.5421.1841. PMID 10364558. 


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