ZDHHC17

Zinc finger, DHHC-type containing 17
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3EU9​
Identifiers
Symbols	ZDHHC17 ; HIP14; HIP3; HSPC294; HYPH
External IDs	OMIM: 607799 MGI: 2445110 HomoloGene: 56324 GeneCards: ZDHHC17 Gene
EC number	2.3.1.225
Gene ontology Molecular function • signal transducer activity • protein binding • zinc ion binding • magnesium ion transmembrane transporter activity • palmitoyltransferase activity • protein-cysteine S-palmitoyltransferase activity • identical protein binding Cellular component • Golgi membrane • cytoplasm • Golgi apparatus • integral component of membrane • Golgi-associated vesicle membrane • intracellular membrane-bounded organelle Biological process • signal transduction • magnesium ion transport • protein palmitoylation • lipoprotein transport • positive regulation of I-kappaB kinase/NF-kappaB signaling Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23390	320150
Ensembl	ENSG00000186908	ENSMUSG00000035798
UniProt	Q8IUH5	Q80TN5
RefSeq (mRNA)	NM_015336	NM_172554
RefSeq (protein)	NP_056151	NP_766142
Location (UCSC)	Chr 12: 76.76 – 76.85 Mb	Chr 10: 110.94 – 111.01 Mb
PubMed search

Palmitoyltransferase ZDHHC17 is an enzyme that contains a DHHC domain that in humans is encoded by the ZDHHC17 gene.^[1][2][3]

Interactions

ZDHHC17 has been shown to interact with Huntingtin.^[4][5]

References

1. Faber PW, Barnes GT, Srinidhi J, Chen J, Gusella JF, MacDonald ME (Sep 1998). "Huntingtin interacts with a family of WW domain proteins". Human Molecular Genetics 7 (9): 1463–74. doi:10.1093/hmg/7.9.1463. PMID 9700202.
2. Goytain A, Hines RM, Quamme GA (Nov 2008). "Huntingtin-interacting proteins, HIP14 and HIP14L, mediate dual functions, palmitoyl acyltransferase and Mg2+ transport". The Journal of Biological Chemistry 283 (48): 33365–74. doi:10.1074/jbc.M801469200. PMC 2662264. PMID 18794299.
3. "Entrez Gene: ZDHHC17 zinc finger, DHHC-type containing 17".
4. Faber PW, Barnes GT, Srinidhi J, Chen J, Gusella JF, MacDonald ME (Sep 1998). "Huntingtin interacts with a family of WW domain proteins". Human Molecular Genetics 7 (9): 1463–74. doi:10.1093/hmg/7.9.1463. PMID 9700202.
5. Singaraja RR, Hadano S, Metzler M, Givan S, Wellington CL, Warby S, Yanai A, Gutekunst CA, Leavitt BR, Yi H, Fichter K, Gan L, McCutcheon K, Chopra V, Michel J, Hersch SM, Ikeda JE, Hayden MR (Nov 2002). "HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis". Human Molecular Genetics 11 (23): 2815–28. doi:10.1093/hmg/11.23.2815. PMID 12393793.

Further reading

• Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Feb 1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032.
• Singaraja RR, Hadano S, Metzler M, Givan S, Wellington CL, Warby S, Yanai A, Gutekunst CA, Leavitt BR, Yi H, Fichter K, Gan L, McCutcheon K, Chopra V, Michel J, Hersch SM, Ikeda JE, Hayden MR (Nov 2002). "HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis". Human Molecular Genetics 11 (23): 2815–28. doi:10.1093/hmg/11.23.2815. PMID 12393793.
• Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, Doi T, Shimotohno K, Harada T, Nishida E, Hayashi H, Sugano S (May 2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501.
• Ducker CE, Stettler EM, French KJ, Upson JJ, Smith CD (Dec 2004). "Huntingtin interacting protein 14 is an oncogenic human protein: palmitoyl acyltransferase". Oncogene 23 (57): 9230–7. doi:10.1038/sj.onc.1208171. PMC 2908390. PMID 15489887.
• Huang K, Yanai A, Kang R, Arstikaitis P, Singaraja RR, Metzler M, Mullard A, Haigh B, Gauthier-Campbell C, Gutekunst CA, Hayden MR, El-Husseini A (Dec 2004). "Huntingtin-interacting protein HIP14 is a palmitoyl transferase involved in palmitoylation and trafficking of multiple neuronal proteins". Neuron 44 (6): 977–86. doi:10.1016/j.neuron.2004.11.027. PMID 15603740.